UniProt Accession

 GAS1_HUMAN; P54826; B9EGM4; Q6B086 

Genbank Protein ID

 L13698; AL158149; BC074908; BC074809; BC132682; BC136586 

Genbank Nucleotide ID

 AAA72368.1; CAH71308.1; AAH74908.1; AAH74809.1; AAI32683.1; AAI36587.1 

Protein Name

 Growth arrest-specific protein 1 

Protein Synonyms/Alias

 GAS-1 

Gene Name

 GAS1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
192	RYLTYCGKVFNGLRC	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Specific growth arrest protein involved in growth suppression. Blocks entry to S phase. Prevents cycling of normal and transformed cells. 

Sequence Annotation

 LIPID 318 318 GPI-anchor amidated serine (Potential).
 CARBOHYD 117 117 N-linked (GlcNAc...) (Potential).  

Keyword

 Cell cycle; Cell membrane; Complete proteome; Glycoprotein; GPI-anchor; Growth arrest; Lipoprotein; Membrane; Reference proteome; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 345 AA 

Protein Sequence

Gene Ontology

 GO:0046658; C:anchored to plasma membrane; ISS:UniProtKB.
 GO:0016021; C:integral to membrane; NAS:UniProtKB.
 GO:0007411; P:axon guidance; IEA:Compara.
 GO:0043010; P:camera-type eye development; IEA:Compara.
 GO:0007050; P:cell cycle arrest; IEA:UniProtKB-KW.
 GO:0045165; P:cell fate commitment; ISS:UniProtKB.
 GO:0035924; P:cellular response to vascular endothelial growth factor stimulus; IEP:UniProtKB.
 GO:0021587; P:cerebellum morphogenesis; IEA:Compara.
 GO:0048589; P:developmental growth; ISS:UniProtKB.
 GO:0021904; P:dorsal/ventral neural tube patterning; IEA:Compara.
 GO:0048701; P:embryonic cranial skeleton morphogenesis; IEA:Compara.
 GO:0042733; P:embryonic digit morphogenesis; IEA:Compara.
 GO:0048592; P:eye morphogenesis; IEA:Compara.
 GO:0042474; P:middle ear morphogenesis; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0030308; P:negative regulation of cell growth; IEA:Compara.
 GO:0050680; P:negative regulation of epithelial cell proliferation; IEA:Compara.
 GO:0045930; P:negative regulation of mitotic cell cycle; IDA:UniProtKB.
 GO:0010955; P:negative regulation of protein processing; IMP:UniProtKB.
 GO:0045879; P:negative regulation of smoothened signaling pathway; IEA:Compara.
 GO:0042476; P:odontogenesis; IEA:Compara.
 GO:0042473; P:outer ear morphogenesis; IEA:Compara.
 GO:0060021; P:palate development; IEA:Compara.
 GO:0050679; P:positive regulation of epithelial cell proliferation; IEA:Compara.
 GO:0002053; P:positive regulation of mesenchymal cell proliferation; IEA:Compara.
 GO:0045880; P:positive regulation of smoothened signaling pathway; IEA:Compara.
 GO:0012501; P:programmed cell death; IEA:Compara.
 GO:0042981; P:regulation of apoptotic process; ISS:UniProtKB.
 GO:0060628; P:regulation of ER to Golgi vesicle-mediated transport; IMP:UniProtKB.
 GO:0008589; P:regulation of smoothened signaling pathway; ISS:UniProtKB. 

Interpro

 IPR016017; GDNF/GAS1. 

Pfam

 PF02351; GDNF 

SMART

 SM00907; GDNF 

PROSITE

  

PRINTS