CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002438
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sodium/proline symporter 
Protein Synonyms/Alias
 Proline permease; Propionate transporter 
Gene Name
 putP 
Gene Synonyms/Alias
 b1015; JW1001 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
121FTGRFEDKSRILRIIacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Catalyzes the sodium-dependent uptake of extracellular L-proline. This protein is also capable of using lithium as the transport cation. Also catalyzes the uptake of propionate. 
Sequence Annotation
 REGION 27 66 Hydrophilic.
 REGION 88 124 Hydrophilic.
 REGION 151 162 Hydrophilic.
 REGION 185 189 Hydrophilic.
 REGION 214 231 Hydrophilic.
 REGION 249 274 Hydrophilic.
 REGION 296 319 Hydrophilic.
 REGION 341 370 Hydrophilic.
 REGION 392 397 Hydrophilic.
 REGION 424 430 Hydrophilic.
 REGION 446 448 Hydrophilic.
 REGION 476 502 Hydrophilic.  
Keyword
 Amino-acid transport; Cell inner membrane; Cell membrane; Complete proteome; Direct protein sequencing; Ion transport; Membrane; Reference proteome; Sodium; Sodium transport; Symport; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 502 AA 
Protein Sequence
MAISTPMLVT FCVYIFGMIL IGFIAWRSTK NFDDYILGGR SLGPFVTALS AGASDMSGWL 60
LMGLPGAVFL SGISESWIAI GLTLGAWINW KLVAGRLRVH TEYNNNALTL PDYFTGRFED 120
KSRILRIISA LVILLFFTIY CASGIVAGAR LFESTFGMSY ETALWAGAAA TILYTFIGGF 180
LAVSWTDTVQ ASLMIFALIL TPVIVIISVG GFGDSLEVIK QKSIENVDML KGLNFVAIIS 240
LMGWGLGYFG QPHILARFMA ADSHHSIVHA RRISMTWMIL CLAGAVAVGF FGIAYFNDHP 300
ALAGAVNQNA ERVFIELAQI LFNPWIAGIL LSAILAAVMS TLSCQLLVCS SAITEDLYKA 360
FLRKHASQKE LVWVGRVMVL VVALVAIALA ANPENRVLGL VSYAWAGFGA AFGPVVLFSV 420
MWSRMTRNGA LAGMIIGALT VIVWKQFGWL GLYEIIPGFI FGSIGIVVFS LLGKAPSAAM 480
QKRFAEADAH YHSAPPSRLQ ES 502 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IDA:EcoCyc.
 GO:0005298; F:proline:sodium symporter activity; IDA:EcoCyc.
 GO:0031402; F:sodium ion binding; IEA:InterPro.
 GO:0015912; P:short-chain fatty acid transport; IMP:EcoCyc. 
Interpro
 IPR011851; Na/Pro_symporter.
 IPR001734; Na/solute_symporter.
 IPR018212; Na/solute_symporter_CS.
 IPR019900; Na/solute_symporter_subgr. 
Pfam
 PF00474; SSF 
SMART
  
PROSITE
 PS00456; NA_SOLUT_SYMP_1
 PS00457; NA_SOLUT_SYMP_2
 PS50283; NA_SOLUT_SYMP_3 
PRINTS