UniProt Accession

 D3Z4U3_MOUSE; D3Z4U3 

Genbank Protein ID

 AC112263; AC136513 

Genbank Nucleotide ID

  

Protein Name

 Ubiquitin-conjugating enzyme E2 K 

Protein Synonyms/Alias

  

Gene Name

 Ube2k 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
14	QRIKREFKEVLKSEE	acetylation	[1]
18	REFKEVLKSEETSKN	acetylation	[1]
24	LKSEETSKNQIKVDL	ubiquitination	[2]
61	GRYQLEIKIPETYPF	ubiquitination	[2]
72	TYPFNPPKVRFITKI	acetylation	[1]
72	TYPFNPPKVRFITKI	ubiquitination	[2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Ligase; Reference proteome; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 157 AA 

Protein Sequence

Gene Ontology

 GO:0004842; F:ubiquitin-protein ligase activity; TAS:MGI.
 GO:0032434; P:regulation of proteasomal ubiquitin-dependent protein catabolic process; IDA:MGI. 

Interpro

 IPR009060; UBA-like.
 IPR000608; UBQ-conjugat_E2.
 IPR023313; UBQ-conjugating_AS.
 IPR016135; UBQ-conjugating_enzyme/RWD. 

Pfam

 PF00179; UQ_con 

SMART

  

PROSITE

 PS00183; UBIQUITIN_CONJUGAT_1
 PS50127; UBIQUITIN_CONJUGAT_2 

PRINTS