CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038049
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Rho guanine nucleotide exchange factor 1 
Protein Synonyms/Alias
  
Gene Name
 Arhgef1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
286APDCRHLKVEADAEKacetylation[1]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 976 AA 
Protein Sequence
MGEVAGGAAP GPPRSGLVSI IIGAEDEDFE NELEANSEDQ NSQFQSLEQV KRRPAHLMAL 60
LQHVALQFEP GPLLCCLHAD MLSSLGPKEA KKAFLDFYHS FLEKTAVLRV PVPPSVAFEL 120
DRTRPDLISE DVQRRFIQEV VQSQQAAVSR QLEDFRSKRL MGMTPWEQEL SLLEPWIGKD 180
RGNYEARERH VAERLLSHLE ETQHTISTDE EKSAAVVTAI SLYMRHLGVR TKSGDKKSGR 240
NFFRKKVMGN RRSDEPPKTK KGLSSILDPA RWNRGEPSAP DCRHLKVEAD AEKPGPADRK 300
GGLGMSSRDR TVGTPGQDNP GVSLHPLSTD SVDSREPGVD TPQEPGDTPP QGPTSLEPLA 360
PPESTEDNGE TERLSGRLGR SESLRVSDRR RPSRGSLGAK GRGGGRSRSD VDMDPGSATA 420
VLGPTRRATP EPGDDGEPGR SGLELEPEEP PGWRELVPPD TLLSLPKSQV KRQEVISELL 480
VTEAAHVRML RVLHDLFYQP MADGGFFPLD ELQNIFPSLD ELIEVHSLFL DRLMKRRQES 540
GYLIEEIGDV LLARFDGAEG SWFQKISSRF CSRQSFALEQ LKAKQRKEPR FCAFVQEAES 600
RPRCRRLQLK DMIPTEMQRL TKYPLLLQSI GQNTEESTER GKVELAAECC REILHHVNQA 660
VRDMEDLLRL KDYQRRLDLT HLRQSSDPML SEFKNLDITK KKLVHEGPLT WRVTKDKAIE 720
VHVLLLDDLL LLLQRQDERL LLKSHSRTLT PTPDGKTMLR PVLRLTSAMT REVATDHKAF 780
YVIFTWDQEA QIYELVAQTS SERKNWCNLI TETAGSLKVP APASRLKPRP SPSSIREPLL 840
SSSENGTGGA EMAPADARTE RLLNDLLPFC RPGPEGQLAA TALQKVLSLK QILLSTEEDS 900
GAGPPRDGDG VPGGRAPGPV HTQEIEENLL SLEVAIRQLE ELEEEFCRLR PLLSQLGGTL 960
SPNLAAPERS AQTGLS 976 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
 GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro. 
Interpro
 IPR000219; DH-domain.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR015212; Regulat_G_prot_signal-like.
 IPR016137; Regulat_G_prot_signal_superfam.
 IPR015721; RhoGEF-like. 
Pfam
 PF09128; RGS-like
 PF00621; RhoGEF 
SMART
 SM00233; PH
 SM00325; RhoGEF 
PROSITE
 PS50010; DH_2
 PS50003; PH_DOMAIN 
PRINTS