| Tag | Content |
|---|
| CPLM ID | CPLM-017945 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Adenosine 3'-phospho 5'-phosphosulfate transporter 1 |
Protein Synonyms/Alias | PAPS transporter 1; Putative MAPK-activating protein PM15; Putative NF-kappa-B-activating protein 48; Solute carrier family 35 member B2 |
Gene Name | SLC35B2 |
Gene Synonyms/Alias | PAPST1; PSEC0149 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 381 | RLKQRGKKAVPVESP | ubiquitination | [1] | | 391 | PVESPVQKV****** | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Mediates the transport of adenosine 3'-phospho 5'- phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. May indirectly participate in activation of the NF- kappa-B and MAPK pathways. |
Sequence Annotation | MOD_RES 427 427 Phosphoserine. |
Keyword | Alternative splicing; Complete proteome; Golgi apparatus; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 432 AA |
Protein Sequence | MDARWWAVVV LAAFPSLGAG GETPEAPPES WTQLWFFRFV VNAAGYASFM VPGYLLVQYF 60
RRKNYLETGR GLCFPLVKAC VFGNEPKASD EVPLAPRTEA AETTPMWQAL KLLFCATGLQ 120
VSYLTWGVLQ ERVMTRSYGA TATSPGERFT DSQFLVLMNR VLALIVAGLS CVLCKQPRHG 180
APMYRYSFAS LSNVLSSWCQ YEALKFVSFP TQVLAKASKV IPVMLMGKLV SRRSYEHWEY 240
LTATLISIGV SMFLLSSGPE PRSSPATTLS GLFTVGSLLE QGALLEGTRF MGRHSEFAAH 300
ALLLSICSAC GQLFIFYTIG QFGAAVFTII MTLRQAFAIL LSCLLYGHTV TVVGGLGVAV 360
VFAALLLRVY ARGRLKQRGK KAVPVESPVQ KV 392 |
Gene Ontology | GO:0000139; C:Golgi membrane; TAS:Reactome. GO:0016021; C:integral to membrane; NAS:UniProtKB. GO:0046964; F:3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity; IDA:UniProtKB. GO:0004871; F:signal transducer activity; IMP:UniProtKB. GO:0046963; P:3'-phosphoadenosine 5'-phosphosulfate transport; IDA:UniProtKB. GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IMP:UniProtKB. |
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Pfam | |
SMART | |
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