| Tag | Content |
|---|
| CPLM ID | CPLM-023859 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Tubulin monoglycylase TTLL3 |
Protein Synonyms/Alias | HOTTL; Tubulin--tyrosine ligase-like protein 3 |
Gene Name | TTLL3 |
Gene Synonyms/Alias | PRO0207 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 102 | NGNPVVMKDGKWVVQ | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Monoglycylase which modifies alpha- and beta-tubulin, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction. |
Sequence Annotation | DOMAIN 151 510 TTL. |
Keyword | Alternative splicing; Cell projection; Cilium; Complete proteome; Cytoplasm; Cytoskeleton; Ligase; Microtubule; Polymorphism; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 772 AA |
Protein Sequence | MDIDKDLEAP LYLTPEGWSL FLQRYYQVVH EGAELRHLDT QVQRCEDILQ QLQAVVPQID 60
MEGDRNIWIV KPGAKSRGRG IMCMDHLEEM LKLVNGNPVV MKDGKWVVQK YIERPLLIFG 120
TKFDLRQWFL VTDWNPLTVW FYRDSYIRFS TQPFSLKNLD NSVHLCNNSI QKHLENSCHR 180
HPLLPPDNMW SSQRFQAHLQ EMGAPNAWST IIVPGMKDAV IHALQTSQDT VQCRKASFEL 240
YGADFVFGED FQPWLIEINA SPTMAPSTAV TARLCAGVQA DTLRVVIDRM LDRNCDTGAF 300
ELIYKQPVTT SPASTPRPSC LLPMYSDTRA RSSDDSTASW WALRPCRPQA RP 352 |
Gene Ontology | GO:0035085; C:cilium axoneme; ISS:UniProtKB. GO:0005874; C:microtubule; IEA:UniProtKB-KW. GO:0015630; C:microtubule cytoskeleton; ISS:UniProtKB. GO:0070736; F:protein-glycine ligase activity, initiating; ISS:UniProtKB. GO:0004835; F:tubulin-tyrosine ligase activity; IEA:InterPro. GO:0035082; P:axoneme assembly; ISS:UniProtKB. GO:0042384; P:cilium assembly; ISS:UniProtKB. GO:0018094; P:protein polyglycylation; IDA:UniProtKB. |
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Pfam | |
SMART | |
PROSITE | |
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