| Tag | Content |
|---|
| CPLM ID | CPLM-012993 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | FAS-associated factor 2 |
Protein Synonyms/Alias | UBX domain-containing protein 8 |
Gene Name | Faf2 |
Gene Synonyms/Alias | Kiaa0887; Ubxd8 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 167 | SQALNDAKRELRFLL | ubiquitination | [1] | | 307 | SLRADQEKERKKREE | ubiquitination | [1] | | 329 | EEEVQQQKLAEERRR | ubiquitination | [1] | | 367 | ESVKIIFKLPNDSRV | ubiquitination | [1] | | 400 | SLKESPEKFQIEANF | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome (By similarity). |
Sequence Annotation | DOMAIN 12 48 UBA.
DOMAIN 357 439 UBX.
MOD_RES 2 2 N-acetylalanine (By similarity).
MOD_RES 167 167 N6-acetyllysine (By similarity). |
Keyword | Acetylation; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Endoplasmic reticulum; Lipid droplet; Reference proteome; Unfolded protein response. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 445 AA |
Protein Sequence | MAAPEEQDLT QEQTEKLLQF QDLTGIESME QCRLALEQHN WNMEAAVQDR LNEQEGVPSV 60
FNPPPARPLQ VNTADHRIYS YVVSRPQPRG LLGWGYYLIM LPFRFTYYTI LDIFRFALRF 120
IRPDPRSRVT DPVGDIVSFM HSFEEKYGRA HPVFYQGTYS QALNDAKREL RFLLVYLHGD 180
DHQDSDEFCR NALCAPEVIS LINSRMLFWA CSTNKPEGYR VSQALRENTY PFLAMIMLKD 240
RRMTVVGRLE GLIQPDDLIN QLTFIMDANQ TYLVSERLER EERNQTQVLR QQQDEAYLAS 300
LRADQEKERK KREEKERKRR KEEEVQQQKL AEERRRQNLQ EEKERKLECL PPEPSPDDPE 360
SVKIIFKLPN DSRVERRFHF SQSLTVIHDF LFSLKESPEK FQIEANFPRR VLPCVPSEEW 420
PNPPTLQEAG LSHTEVLFVQ DLTDE 445 |
Gene Ontology | GO:0034098; C:Cdc48p-Npl4p-Ufd1p AAA ATPase complex; IEA:Compara. GO:0005811; C:lipid particle; IEA:UniProtKB-SubCell. GO:0006986; P:response to unfolded protein; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |