| Tag | Content |
|---|
| CPLM ID | CPLM-015799 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Histone H2B |
Protein Synonyms/Alias | |
Gene Name | |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Tetrahymena pyriformis |
NCBI Taxa ID | 5908 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 5 | ***MAPKKAPAAAEK | acetylation | [1, 2] |
|
Reference | [1] Histone acetylation in replication and transcription: turnover at specific acetylation sites in histone H4 from Physarum polycephalum. Pesis KH, Matthews HR. Arch Biochem Biophys. 1986 Dec;251(2):665-73. [ PMID: 3800393] [2] Tetrahymena histone H2B. Complete amino acid sequence. Nomoto M, Hayashi H, Iwai K. J Biochem. 1982 Mar;91(3):897-904. [ PMID: 6804458] |
Functional Description | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
Sequence Annotation | MOD_RES 2 2 N,N,N-trimethylalanine.
MOD_RES 5 5 N6-acetyllysine.
MOD_RES 41 41 N6-acetyllysine (By similarity).
CROSSLNK 115 115 Glycyl lysine isopeptide (Lys-Gly) |
Keyword | Acetylation; Chromosome; Direct protein sequencing; DNA-binding; Isopeptide bond; Methylation; Nucleosome core; Nucleus; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 121 AA |
Protein Sequence | MAPKKAPAAA EKKVKKAPTT EKKNKKKRSE TFAIYIFKVL KQVHPDVGIS KKAMNIMNSF 60
INDSFERIAL ESSKLVRFNK RRTLSSREVQ TAVKLLLPGE LARHAISEGT KAVTKFSSST 120
N 121 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |