CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004511
UniProt Accession
Genbank Protein ID
 D90038 
Genbank Nucleotide ID
Protein Name
 ATP-binding cassette sub-family D member 3 
Protein Synonyms/Alias
 70 kDa peroxisomal membrane protein; PMP70 
Gene Name
 Abcd3 
Gene Synonyms/Alias
 Pmp70; Pxmp1 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
260KMTIMEQKYEGEYRFubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113
Functional Description
  
Sequence Annotation
 DOMAIN 85 372 ABC transmembrane type-1.
 DOMAIN 434 659 ABC transporter.
 NP_BIND 473 480 ATP (Potential).
 REGION 2 199 Interaction with PEX19 (By similarity).
 REGION 2 124 Targeting to peroxisomes (By similarity).
 MOD_RES 260 260 N6-acetyllysine (By similarity).
 MOD_RES 399 399 N6-acetyllysine (By similarity).
 MOD_RES 424 424 Phosphoserine (By similarity).
 CARBOHYD 12 12 N-linked (GlcNAc...) (Potential).
 CARBOHYD 106 106 N-linked (GlcNAc...) (Potential).
 CARBOHYD 206 206 N-linked (GlcNAc...) (Potential).  
Keyword
 Acetylation; ATP-binding; Complete proteome; Direct protein sequencing; Glycoprotein; Membrane; Nucleotide-binding; Peroxisome; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 659 AA 
Protein Sequence
MAAFSKYLTA RNSSLAGAAF LLFCLLHKRR RALGLHGKKS GKPPLQNNEK EGKKERAVVD 60
KVFLSRLSQI LKIMVPRTFC KETGYLILIA VMLVSRTYCD VWMIQNGTLI ESGIIGRSSK 120
DFKRYLFNFI AAMPLISLVN NFLKYGLNEL KLCFRVRLTR YLYEEYLQAF TYYKMGNLDN 180
RIANPDQLLT QDVEKFCNSV VDLYSNLSKP FLDIVLYIFK LTSAIGAQGP ASMMAYLLVS 240
GLFLTRLRRP IGKMTIMEQK YEGEYRFVNS RLITNSEEIA FYNGNKREKQ TIHSVFRKLV 300
EHLHNFIFFR FSMGFIDSII AKYIATVVGY LVVSRPFLDL AHPRHLHSTH SELLEDYYQS 360
GRMLLRMSQA LGRIVLAGRE MTRLAGFTAR ITELMQVLKD LNHGKYERTM VSQQDKGIEG 420
AQASPLIPGA GEIINADNII KFDHVPLATP NGDILIQDLS FEVRSGANVL ICGPNGCGKS 480
SLFRVLGELW PLFGGHLTKP ERGKLFYVPQ RPYMTLGTLR DQVIYPDGKE DQKKKGISDQ 540
VLKGYLDNVQ LGHILEREGG WDSVQDWMDV LSGGEKQRMA MARLFYHKPQ FAILDECTSA 600
VSVDVEDYIY SHCRKVGITL FTVSHRKSLW KHHEYYLHMD GRGNYEFKKI TEDTVEFGS 659 
Gene Ontology
 GO:0016021; C:integral to membrane; NAS:RGD.
 GO:0005739; C:mitochondrion; IDA:UniProtKB.
 GO:0005778; C:peroxisomal membrane; IDA:HGNC.
 GO:0005524; F:ATP binding; IDA:RGD.
 GO:0042626; F:ATPase activity, coupled to transmembrane movement of substances; TAS:RGD.
 GO:0043621; F:protein self-association; IDA:RGD.
 GO:0015910; P:peroxisomal long-chain fatty acid import; TAS:RGD.
 GO:0042493; P:response to drug; IEP:RGD. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR010509; ABC_Ald_N.
 IPR003439; ABC_transporter-like.
 IPR017871; ABC_transporter_CS.
 IPR017940; ABC_transporter_type1.
 IPR011527; ABC_transptrTM_dom_typ1.
 IPR005283; FA_transporter.
 IPR027417; P-loop_NTPase. 
Pfam
 PF06472; ABC_membrane_2
 PF00005; ABC_tran 
SMART
 SM00382; AAA 
PROSITE
 PS50929; ABC_TM1F
 PS00211; ABC_TRANSPORTER_1
 PS50893; ABC_TRANSPORTER_2 
PRINTS