UniProt Accession

 EAF6_MOUSE; Q2VPQ9; B1ASC6; Q9D7J5 

Genbank Protein ID

 AK009177; AL626775; BC108404 

Genbank Nucleotide ID

 BAB26123.1; CAM20901.1; AAI08405.1 

Protein Name

 Chromatin modification-related protein MEAF6 

Protein Synonyms/Alias

 MYST/Esa1-associated factor 6; Esa1-associated factor 6 homolog; Protein EAF6 homolog 

Gene Name

 Meaf6 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
6	**MAMHNKTAPPQIP	acetylation	[1, 2]
26	LAELVKRKQELAETL	ubiquitination	[3]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (By similarity). 

Sequence Annotation

 MOD_RES 69 69 N6-acetyllysine (By similarity).
 MOD_RES 74 74 N6-acetyllysine (By similarity).
 MOD_RES 118 118 Phosphoserine (By similarity).
 MOD_RES 120 120 Phosphothreonine (By similarity).  

Keyword

 Acetylation; Activator; Alternative splicing; Chromatin regulator; Coiled coil; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 191 AA 

Protein Sequence

Gene Ontology

 GO:0005813; C:centrosome; IEA:Compara.
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0070776; C:MOZ/MORF histone acetyltransferase complex; ISS:UniProtKB.
 GO:0035267; C:NuA4 histone acetyltransferase complex; ISS:UniProtKB.
 GO:0005730; C:nucleolus; ISS:UniProtKB.
 GO:0043968; P:histone H2A acetylation; ISS:UniProtKB.
 GO:0044154; P:histone H3-K14 acetylation; ISS:UniProtKB.
 GO:0043983; P:histone H4-K12 acetylation; ISS:UniProtKB.
 GO:0043981; P:histone H4-K5 acetylation; ISS:UniProtKB.
 GO:0043982; P:histone H4-K8 acetylation; ISS:UniProtKB.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR015418; Hist_AcTrfase_NuA4_cplx. 

Pfam

 PF09340; NuA4 

SMART

  

PROSITE

  

PRINTS