UniProt Accession

 PYRH_ECOLI; P0A7E9; P29464 

Genbank Protein ID

 X78809; D13334; U70214; U00096; AP009048 

Genbank Nucleotide ID

 CAA55388.1; BAA02598.1; AAB08600.1; AAC73282.1; BAB96747.1 

Protein Name

 Uridylate kinase 

Protein Synonyms/Alias

 UK; Uridine monophosphate kinase; UMP kinase; UMPK 

Gene Name

 pyrH 

Gene Synonyms/Alias

 smbA; b0171; JW0166 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
68	FRGAGLAKAGMNRVV	acetylation	[1]
166	DVVLKATKVDGVFTA	acetylation	[1]
177	VFTADPAKDPTATMY	acetylation	[1]
195	TYSEVLEKELKVMDL	acetylation	[1]
198	EVLEKELKVMDLAAF	acetylation	[1]
212	FTLARDHKLPIRVFN	acetylation	[1]
222	IRVFNMNKPGALRRV	acetylation	[1]
234	RRVVMGEKEGTLITE	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Catalyzes the reversible phosphorylation of UMP to UDP, with ATP as the most efficient phosphate donor. 

Sequence Annotation

 NP_BIND 15 18 ATP (By similarity).
 NP_BIND 138 145 UMP.
 REGION 23 28 Involved in allosteric activation by GTP
 BINDING 57 57 UMP; via amide nitrogen.
 BINDING 58 58 ATP; via amide nitrogen (By similarity).
 BINDING 62 62 ATP (By similarity).
 BINDING 77 77 UMP.
 BINDING 165 165 ATP (By similarity).
 BINDING 171 171 ATP; via amide nitrogen and carbonyl
 BINDING 174 174 ATP (By similarity).  

Keyword

 3D-structure; Allosteric enzyme; ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Kinase; Nucleotide-binding; Pyrimidine biosynthesis; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 241 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:EcoCyc.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0042802; F:identical protein binding; IDA:EcoCyc.
 GO:0033862; F:UMP kinase activity; IDA:EcoCyc.
 GO:0044210; P:'de novo' CTP biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0008652; P:cellular amino acid biosynthetic process; IEA:InterPro. 

Interpro

 IPR001048; Asp/Glu/Uridylate_kinase.
 IPR011817; Uridylate_kinase.
 IPR015963; Uridylate_kinase_bac. 

Pfam

 PF00696; AA_kinase 

SMART

  

PROSITE

  

PRINTS