CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015225
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Connector enhancer of kinase suppressor of ras 3 
Protein Synonyms/Alias
 Connector enhancer of KSR 3; CNK homolog protein 3; CNK3; CNKSR family member 3; Maguin-like protein 
Gene Name
 CNKSR3 
Gene Synonyms/Alias
 MAGI1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
305NFTPAPLKNLRWKPPubiquitination[1, 2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Probably involved in transepithelial sodium transport. Regulates aldosterone-induced and ENaC-mediated sodium transport possibly through regulation of the ERK pathway (By similarity). 
Sequence Annotation
 DOMAIN 7 72 SAM.
 DOMAIN 80 174 CRIC.
 DOMAIN 211 293 PDZ.
 DOMAIN 325 546 DUF1170.
 MOD_RES 381 381 Phosphoserine (By similarity).  
Keyword
 Complete proteome; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 555 AA 
Protein Sequence
MEPVTKWSPK QVVDWTRGLD DCLQQYVHKF EREKINGEQL LQISHQDLEE LGVTRIGHQE 60
LVLEAVDLLC ALNYGLETDN MKNLVLKLRA SSHNLQNYIS SRRKSPAYDG NTSRKAPNEF 120
LTSVVELIGA AKALLAWLDR APFTGITDFS VTKNKIIQLC LDLTTTVQKD CFVAEMEDKV 180
LTVVKVLNGI CDKTIRSTTD PVMSQCACLE EVHLPNIKPG EGLGMYIKST YDGLHVITGT 240
TENSPADRSQ KIHAGDEVIQ VNQQTVVGWQ LKNLVKKLRE NPTGVVLLLK KRPTGSFNFT 300
PAPLKNLRWK PPLVQTSPPP ATTQSPESTM DTSLKKEKSA ILDLYIPPPP AVPYSPRDEN 360
GSFVYGGSSK CKQPLPGPKG SESPNSFLDQ ESRRRRFTIA DSDQLPGYSV ETNILPTKMR 420
EKTPSYGKPR PLSMPADGNW MGIVDPFARP RGHGRKGEDA LCRYFSNERI PPIIEESSSP 480
PYRFSRPTTE RHLVRGADYI RGSRCYINSD LHSSATIPFQ EEGTKKKSGS SATKSSSTEP 540
SLLVSWFTRL KLLTH 555 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0016020; C:membrane; IEA:InterPro.
 GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.
 GO:0033137; P:negative regulation of peptidyl-serine phosphorylation; ISS:UniProtKB.
 GO:0010765; P:positive regulation of sodium ion transport; ISS:UniProtKB. 
Interpro
 IPR010599; CNKSR2.
 IPR017874; CRIC_domain.
 IPR019555; CRIC_domain_Chordata.
 IPR001478; PDZ.
 IPR001660; SAM.
 IPR013761; SAM/pointed.
 IPR021129; SAM_type1. 
Pfam
 PF10534; CRIC_ras_sig
 PF06663; DUF1170
 PF00595; PDZ
 PF00536; SAM_1 
SMART
 SM00228; PDZ
 SM00454; SAM 
PROSITE
 PS51290; CRIC
 PS50106; PDZ
 PS50105; SAM_DOMAIN 
PRINTS