CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013701
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Migration and invasion-inhibitory protein 
Protein Synonyms/Alias
 IGFBP2-binding protein; Invasion-inhibitory protein 45; IIp45 
Gene Name
 MIIP 
Gene Synonyms/Alias
 IIP45 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
151SILAQQSKLSKPRVTubiquitination[1]
154AQQSKLSKPRVTFSEubiquitination[1]
210QEFRETNKEECICSHubiquitination[1]
326GWDIFPPKSEKSSAPubiquitination[1]
329IFPPKSEKSSAPRNLubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. Exhibits opposing effects to IGFBP2 on cell invasion. 
Sequence Annotation
 REGION 239 282 Interaction with IGFBP2.
 MOD_RES 303 303 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 388 AA 
Protein Sequence
MVEAEELAQL RLLNLELLRQ LWVGQDAVRR SVARAASESS LESSSSYNSE TPSTPETSST 60
SLSTSCPRGR SSVWGPPDAC RGDLRDVARS GVASLPPAKC QHQESLGRPR PHSAPSLGTS 120
SLRDPEPSGR LGDPGPQEAQ TPRSILAQQS KLSKPRVTFS EESAVPKRSW RLRPYLGYDW 180
IAGSLDTSSS ITSQPEAFFS KLQEFRETNK EECICSHPEP QLPGLRESSG SGVEEDHECV 240
YCYRVNRRLF PVPVDPGTPC RLCRTPRDQQ GPGTLAQPAH VRVSIPLSIL EPPHRYHIHR 300
RKSFDASDTL ALPRHCLLGW DIFPPKSEKS SAPRNLDLWS SVSAEAQHQK LSGTSSPFHP 360
ASPMQMLPPT PTWSVPQVPR PHVPRQKP 388 
Gene Ontology
  
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS