CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039054
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Isoleucine-tRNA synthetase (Predicted) 
Protein Synonyms/Alias
 Protein Iars 
Gene Name
 Iars 
Gene Synonyms/Alias
 Iars_predicted; rCG_44151 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
617DPVSIINKYGADALRacetylation[1]
844DRKTIPIKYPLKEIVacetylation[1]
1042ATIKAPLKPYPVPTSacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Aminoacyl-tRNA synthetase; Complete proteome; Ligase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1262 AA 
Protein Sequence
MVQQVPENIS FPAEEEKILQ FWSKYNCFQE CLKQSKLRPK FTFYDGPPFA TGLPHYGHIL 60
AGTIKDIVTR YAHQSGFHVD RRFGWDCHGL PVEYEIDKTL GIKGPEDVAK MGIAEYNKQC 120
RAIVMRYSAE WKSTVTRLGR WIDFDNDYKT LYPQFMESVW WVFKQLYDKG LVYRGVKVMP 180
FSTACGTPLS NFESNQNYKD VQDPSVFVTF PLEEDENTSL VAWTTTPWTL PSNLALCVNP 240
EIQYVKIKDV SRGKLFILME ARLSALYKQE SDYEILERFP GASLKGKKYK PLFDYFIKCK 300
ENGAFTVLVD HYVKDEEGTG VVHQAPYFGA DDHRVCMDFN IIQKDSAPVC PVDASGCFTE 360
EVTHFVGQYV KDADKNIIRM LKEQGRLLVA STFTHSYPFC WRSDTPLIYK SVPSWFVRVE 420
HMVDQLLKNN DLCYWVPEFV REKRFGNWLK EARDWAISRN RYWGTPIPLW VSEDFEEVVC 480
IGSVAELEEL SGTKISDLHR ESIDHLTIPS RCGKGPLRRV SEVFDCWFES GSMPYAQVHY 540
PFESKREFED AFPADFIAEG IDQTRGWFYT LLVLATALFG QPPFKNVIVN GLILASDGQK 600
MSKRKKNYPD PVSIINKYGA DALRLYLINS PVVRAENLRF KEEGVRDVLK DVLLPWYNAY 660
RFFIQNVFRL HKEEEVEFLY NEHTVRESPN ITDRWILSFM QSLIAFFETE MAAYRLYTVV 720
PRLVKFVDIL TNWYVRMNRR RLKGENGMED CVMALETLFS VLLSLCRLMA PYTPFLTELM 780
YQNLKLLIDP ASIRDKDTLS IHYLMLPHVR EELIDKKTEN AVSRMQSVIE LGRVIRDRKT 840
IPIKYPLKEI VVIHQDPEAL EDIKSLEKYI IEELNVRKVT LSTDKNKYGI RLRAEPDHMV 900
LGKRLKGAFK AVMVAVKQLS NEELEQFQKS GSIVVEGHEL HEEDIRLMYT FDQATGGTAQ 960
FEAHSDAQAL VLLDVTPDQS MVDEGMAREV INRIQKLRKK CNLVPTDEIT VYYNAKSEGR 1020
YLSNVIESHT DFIYATIKAP LKPYPVPTSD NILIQEQTQL KGYELEITIT RGSCVPGPAC 1080
AYVNLNICAN GTEQGGVLLL ENPKGDNQLN LEKLKSVITS IFGVKSTGLS VFNGGTELQN 1140
QTDLLSLSGR TLCVTAGASL APASSPSTLL CQYINLQLVN AEPQECLTGT VGTLLLENPL 1200
GQNGLTHQGL VYEAAKVFGL RSRRLKLFLN ETQTQEITED IPMKTLNMKT VYVSVLPTTA 1260
DG 1262 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0002161; F:aminoacyl-tRNA editing activity; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0004822; F:isoleucine-tRNA ligase activity; IEA:InterPro.
 GO:0006428; P:isoleucyl-tRNA aminoacylation; IEA:InterPro.
 GO:0006450; P:regulation of translational fidelity; IEA:GOC. 
Interpro
 IPR001412; aa-tRNA-synth_I_CS.
 IPR002300; aa-tRNA-synth_Ia.
 IPR002301; Ile-tRNA-ligase.
 IPR023586; Ile-tRNA-ligase_type2.
 IPR014729; Rossmann-like_a/b/a_fold.
 IPR009080; tRNAsynth_1a_anticodon-bd.
 IPR013155; V/L/I-tRNA-synth_anticodon-bd.
 IPR009008; Val/Leu/Ile-tRNA-synth_edit. 
Pfam
 PF08264; Anticodon_1
 PF00133; tRNA-synt_1 
SMART
  
PROSITE
 PS00178; AA_TRNA_LIGASE_I 
PRINTS
 PR00984; TRNASYNTHILE.