CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037799
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Baculoviral IAP repeat-containing protein 2 
Protein Synonyms/Alias
  
Gene Name
 BIRC2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
15SDWTNSNKQKMKYDFubiquitination[1]
17WTNSNKQKMKYDFSCubiquitination[1]
19NSNKQKMKYDFSCELubiquitination[1, 2]
59YYTGVNDKVKCFCCGubiquitination[1]
73GLMLDNWKLGDSPIQubiquitination[1]
81LGDSPIQKHKQLYPSubiquitination[1]
105ASLGSTSKNTSPMRNubiquitination[1, 2, 3]
205ACFACGGKLSNWEPKubiquitination[1, 2]
212KLSNWEPKDDAMSEHubiquitination[1, 2, 4, 5, 6, 7]
284VGRNDDVKCFCCDGGubiquitination[1, 8]
319CEFLIRMKGQEFVDEubiquitination[5]
589PICRGIIKGTVRTFLubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] A data set of human endogenous protein ubiquitination sites.
 Shi Y, Chan DW, Jung SY, Malovannaya A, Wang Y, Qin J.
 Mol Cell Proteomics. 2011 May;10(5):M110.002089. [PMID: 20972266]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [6] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [7] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [8] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 597 AA 
Protein Sequence
MEDSTILSDW TNSNKQKMKY DFSCELYRMS TYSTFPAGVP VSERSLARAG FYYTGVNDKV 60
KCFCCGLMLD NWKLGDSPIQ KHKQLYPSCS FIQNLVSASL GSTSKNTSPM RNSFAHSLSP 120
TLEHSSLFSG SYSSLSPNPL NSRAVEDISS SRTNPYSYAM STEEARFLTY HMWPLTFLSP 180
SELARAGFYY IGPGDRVACF ACGGKLSNWE PKDDAMSEHR RHFPNCPFLE NSLETLRFSI 240
SNLSMQTHAA RMRTFMYWPS SVPVQPEQLA SAGFYYVGRN DDVKCFCCDG GLRCWESGDD 300
PWVEHAKWFP RCEFLIRMKG QEFVDEIQGR YPHLLEQLLS TSDTTGEENA DPPIIHFGPG 360
ESSSEDAVMM NTPVVKSALE MGFNRDLVKQ TVQSKILTTG ENYKTVNDIV SALLNAEDEK 420
REEEKEKQAE EMASDDLSLI RKNRMALFQQ LTCVLPILDN LLKANVINKQ EHDIIKQKTQ 480
IPLQARELID TILVKGNAAA NIFKNCLKEI DSTLYKNLFV DKNMKYIPTE DVSGLSLEEQ 540
LRRLQEERTC KVCMDKEVSV VFIPCGHLVV CQECAPSLRK CPICRGIIKG TVRTFLS 597 
Gene Ontology
 GO:0035631; C:CD40 receptor complex; IEA:Compara.
 GO:0009898; C:internal side of plasma membrane; IEA:Compara.
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0070266; P:necroptosis; IEA:Compara.
 GO:0001890; P:placenta development; IEA:Compara.
 GO:0042981; P:regulation of apoptotic process; IEA:Compara. 
Interpro
 IPR001370; BIR.
 IPR001315; CARD.
 IPR011029; DEATH-like_dom.
 IPR001841; Znf_RING. 
Pfam
 PF00653; BIR
 PF00619; CARD 
SMART
 SM00238; BIR
 SM00114; CARD
 SM00184; RING 
PROSITE
 PS01282; BIR_REPEAT_1
 PS50143; BIR_REPEAT_2
 PS50209; CARD
 PS50089; ZF_RING_2 
PRINTS