| Tag | Content |
|---|
| CPLM ID | CPLM-017870 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Sodium/hydrogen exchanger 8 |
Protein Synonyms/Alias | Na(+)/H(+) exchanger 8; NHE-8; Solute carrier family 9 member 8 |
Gene Name | Slc9a8 |
Gene Synonyms/Alias | Nhe8 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 551 | HHGRIQMKSLTNKWY | ubiquitination | [1] | | 556 | QMKSLTNKWYEEVRQ | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction (By similarity). |
Sequence Annotation | MOD_RES 566 566 Phosphoserine (By similarity).
MOD_RES 568 568 Phosphoserine (By similarity). |
Keyword | Alternative splicing; Antiport; Complete proteome; Golgi apparatus; Ion transport; Membrane; Phosphoprotein; Reference proteome; Sodium; Sodium transport; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 576 AA |
Protein Sequence | MAEEEFSNTT HETFNFTLHT TLGVTTKLVL PTPAKPILPV QTGEQAQQEE QSSGMTIFFS 60
LLVLAICIIL VHLLIRYRLH FLPESVAVVS LGILMGAVIK VIEFKKLANW KEEEMFRPNM 120
FFLLLLPPII FESGYSLHKG NFFQNIGSIT LFAVFGTAIS AFVVGGGIYF LGQADVISKL 180
NMTDSFAFGS LISAVDPVAT IAIFNALHVD PVLNMLVFGE SILNDAVSIV LTNTAEGLTR 240
KHMSDVSGWQ TFSQALGYFL KMFFGSAALG TLTGLISALV LKHIDLRKTP SLEFGMMIIF 300
AYLPYGLAEG ISLSGIMAIL FSGIVMSHYT HHNLSPVTQI LMQQTLRTVA FLCETCVFAF 360
LGLSIFSFPH KFEISFVIWC IVLVLFGRAV NIFPLSYLLN FFRDHKITPK MMFIMWFSGL 420
RGAIPYALSL HLGLEPMEKR QLIGTTTIVI VLFTILLLGG STMPLIRLVD IEDARARRRS 480
KKDVNLSKTE KMGNAIESEH LSELTEEEYE AHYIRQQDLK GFMWLDAKYL NPFFTRRLTQ 540
EDLHHGRIQM KSLTNKWYEE VRQGPSGSED DEQELF 576 |
Gene Ontology | GO:0005794; C:Golgi apparatus; IDA:MGI. GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0015386; F:potassium:hydrogen antiporter activity; IDA:MGI. GO:0015385; F:sodium:hydrogen antiporter activity; IDA:MGI. GO:0051453; P:regulation of intracellular pH; IDA:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |