CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016031
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Mitofusin-2 
Protein Synonyms/Alias
 Hypertension-related protein 1; Mitochondrial assembly regulatory factor; HSG protein; Transmembrane GTPase MFN2 
Gene Name
 Mfn2 
Gene Synonyms/Alias
 Kiaa0214; Marf 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
30EVNASPLKHFVTAKKubiquitination[1]
84DVKGYLSKVRGISEVubiquitination[1]
720EIAAMNKKVEALDSLubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN2 acts independently of the cytoskeleton. It therefore plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Overexpression induces the formation of mitochondrial networks. Plays an important role in the regulation of vascular smooth muscle cell proliferation. 
Sequence Annotation
 NP_BIND 103 110 GTP (Probable).
 NP_BIND 199 203 GTP (Probable).
 NP_BIND 258 261 GTP (Probable).  
Keyword
 Alternative splicing; Coiled coil; Complete proteome; Developmental protein; Direct protein sequencing; GTP-binding; Hydrolase; Membrane; Mitochondrion; Mitochondrion outer membrane; Nucleotide-binding; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 757 AA 
Protein Sequence
MSLLFSRCNS IVTVKKDKRH MAEVNASPLK HFVTAKKKIN GIFEQLGAYI QESASFLEDT 60
HRNTELDPVT TEEQVLDVKG YLSKVRGISE VLARRHMKVA FFGRTSNGKS TVINAMLWDK 120
VLPSGIGHTT NCFLRVGGTD GHEAFLLTEG SEEKKSVKTV NQLAHALHQD EQLHAGSMVS 180
VMWPNSKCPL LKDDLVLMDS PGIDVTTELD SWIDKFCLDA DVFVLVANSE STLMQTEKQF 240
FHKVSERLSR PNIFILNNRW DASASEPEYM EEVRRQHMER CTSFLVDELG VVDRAQAGDR 300
IFFVSAKEVL SARVQKAQGM PEGGGALAEG FQVRMFEFQN FERQFEECIS QSAVKTKFEQ 360
HTVRAKQIAE AVRLIMDSLH IAAQEQRVYC LEMREERQDR LRFIDKQLEL LAQDYKLRIK 420
QITEEVERQV STAMAEEIRR LSVLVDEYQM DFHPSPVVLK VYKNELHRHI EEGLGRNLSD 480
RCSTAIASSL QTMQQDMIDG LKPLLPVSMR NQIDMLVPRQ CFSLSYDLNC DKLCADFQED 540
IEFHFSLGWT MLVNRFLGPK NSRRALLGYS DQVQRPLPLT PANPSMPPLP QSSLTQEELM 600
VSMVTGLASL TSRTSMGILV VGGVVWKAVG WRLIALSFGL YGLLYVYERL TWTTKAKERA 660
FKRQFVEYAS EKLQLIISYT GSNCSHQVQQ ELSGTFAHLC QQVDITRDNL EQEIAAMNKK 720
VEALDSLQSR AKLLRNKAGW LDSELNMFTH QYLQPSR 757 
Gene Ontology
 GO:0005829; C:cytosol; ISS:UniProtKB.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0031306; C:intrinsic to mitochondrial outer membrane; ISS:UniProtKB.
 GO:0015630; C:microtubule cytoskeleton; IDA:MGI.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; IEA:InterPro.
 GO:0001825; P:blastocyst formation; IMP:MGI.
 GO:0048593; P:camera-type eye morphogenesis; IMP:MGI.
 GO:0008053; P:mitochondrial fusion; IMP:MGI.
 GO:0007006; P:mitochondrial membrane organization; ISS:UniProtKB.
 GO:0051646; P:mitochondrion localization; ISS:UniProtKB.
 GO:0046580; P:negative regulation of Ras protein signal transduction; IEA:Compara.
 GO:0048662; P:negative regulation of smooth muscle cell proliferation; ISS:UniProtKB.
 GO:0006626; P:protein targeting to mitochondrion; ISS:UniProtKB. 
Interpro
 IPR001401; Dynamin_GTPase.
 IPR006884; Fzo/mitofusin_HR2.
 IPR027089; Mitofusin-2.
 IPR027094; Mitofusin_fam.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00350; Dynamin_N
 PF04799; Fzo_mitofusin 
SMART
  
PROSITE
  
PRINTS