| Tag | Content |
|---|
| CPLM ID | CPLM-001427 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Potassium voltage-gated channel subfamily KQT member 2 |
Protein Synonyms/Alias | KQT-like 2; Potassium channel subunit alpha KvLQT2; Voltage-gated potassium channel subunit Kv7.2 |
Gene Name | Kcnq2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 49 | IAGSEAPKRGSVLSK | ubiquitination | [1] | | 66 | TGGAGAGKPPKRNAF | ubiquitination | [1] | | 589 | ITDKDRTKGPAETEL | ubiquitination | [1] | | 618 | KQVLSMEKKLDFLVS | ubiquitination | [1] |
|
Reference | [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J. J Proteome Res. 2012 Sep 7;11(9):4722-32. [ PMID: 22871113] |
Functional Description | Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. KCNQ2 current is blocked by barium and tetraethylammonium whereas 4-aminopyridine and charybdotoxin have no effect on KCNQ2 current. Tyrosine kinase inhibitors genistein or herbimycin a markedly down-regulate KCNQ2 current. Muscarinic agonist oxotremorine-M suppress KCNQ2/KCNQ3 current in CHO cells in which cloned KCNQ2/KCNQ3 channels were coexpressed with human M1 muscarinic receptors. |
Sequence Annotation | MOTIF 277 282 Selectivity filter (By similarity).
MOD_RES 52 52 Phosphoserine; by PKA (By similarity).
MOD_RES 448 448 Phosphoserine (By similarity).
MOD_RES 450 450 Phosphoserine (By similarity). |
Keyword | Alternative splicing; Complete proteome; Ion channel; Ion transport; Membrane; Phosphoprotein; Potassium; Potassium channel; Potassium transport; Reference proteome; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 852 AA |
Protein Sequence | MVQKSRNGGV YPGTSGEKKL KVGFVGLDPG APDSTRDGAL LIAGSEAPKR GSVLSKPRTG 60
GAGAGKPPKR NAFYRKLQNF LYNVLERPRG WAFIYHAYVF LLVFSCLVLS VFSTIKEYEK 120
SSEGALYILE IVTIVVFGVE YFVRIWAAGC CCRYRGWRGR LKFARKPFCV IDIMVLIASI 180
AVLAAGSQGN VFATSALRSL RFLQILRMIR MDRRGGTWKL LGSVVYAHSK ELVTAWYIGF 240
LCLILASFLV YLAEKGENDH FDTYADALWW GLITLTTIGY GDKYPQTWNG RLLAATFTLI 300
GVSFFALPAG ILGSGFALKV QEQHRQKHFE KRRNPAAGLI QSAWRFYATN LSRTDLHSTW 360
QYYERTVTVP MISSQTQTYG ASRLIPPLNQ LEMLRNLKSK SGLTFRKEPQ PEPSPSQKVS 420
LKDRVFSSPR GVAAKGKGSP QAQTVRRSPS ADQSLDDSPS KVPKSWSFGD RSRARQAFRI 480
KGAASRQNSE EASLPGEDIV EDNKSCNCEF VTEDLTPGLK VSIRAVCVMR FLVSKRKFKE 540
SLRPYDVMDV IEQYSAGHLD MLSRIKSLQS RVDQIVGRGP TITDKDRTKG PAETELPEDP 600
SMMGRLGKVE KQVLSMEKKL DFLVSIYTQR MGIPPAETEA YFGAKEPEPA PPYHSPEDSR 660
DHADKHGCII KIVRSTSSTG QRKYAAPPVM PPAECPPSTS WQQSHQRHGT SPVGDHGSLV 720
RIPPPPAHER SLSAYSGGNR ASTEFLRLEG TPACRPSEAA LRDSDTSISI PSVDHEELER 780
SFSGFSISQS KENLNALASC YAAVAPCAKV RPYIAEGESD TDSDLCTPCG PPPRSATGEG 840
PFGDVAWAGP RK 852 |
Gene Ontology | GO:0043234; C:protein complex; IDA:RGD. GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro. GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |