| Tag | Content |
|---|
| CPLM ID | CPLM-020207 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Telomerase Cajal body protein 1 |
Protein Synonyms/Alias | WD repeat-containing protein 79; WD40 repeat-containing protein encoding RNA antisense to p53 |
Gene Name | WRAP53 |
Gene Synonyms/Alias | TCAB1; WDR79 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 173 | TQPENFLKGCKWAPD | ubiquitination | [1] | | 176 | ENFLKGCKWAPDGSC | ubiquitination | [1] | | 321 | VRATFAKKQGQSGII | ubiquitination | [1] | | 388 | RFFSGARKDAELLCW | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes. In the telomerase holoenzyme complex, it controls telomerase localization to Cajal body. Required for delivery of TERC to telomeres during S phase and for telomerase activity. Binds small Cajal body RNAs (scaRNAs). The mRNA encoding this protein plays a critical role in the regulation of p53 expression at the post- transcriptional level; it is involved both in maintaining basal p53 mRNA levels and in p53 induction upon DNA damage. |
Sequence Annotation | REPEAT 167 206 WD 1.
REPEAT 222 267 WD 2.
REPEAT 272 313 WD 3.
REPEAT 323 364 WD 4.
REPEAT 365 405 WD 5.
REPEAT 411 450 WD 6.
MOD_RES 26 26 Phosphoserine.
MOD_RES 30 30 Phosphoserine.
MOD_RES 54 54 Phosphoserine.
MOD_RES 85 85 Phosphoserine.
MOD_RES 90 90 Phosphoserine.
MOD_RES 112 112 Phosphoserine.
MOD_RES 114 114 Phosphoserine.
MOD_RES 489 489 Phosphothreonine.
MOD_RES 491 491 Phosphoserine. |
Keyword | Complete proteome; Cytoplasm; Disease mutation; Dyskeratosis congenita; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; RNA-binding; WD repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 548 AA |
Protein Sequence | MKTLETQPLA PDCCPSDQDP APAHPSPHAS PMNKNADSEL MPPPPERGDP PRLSPDPVAG 60
SAVSQELREG DPVSLSTPLE TEFGSPSELS PRIEEQELSE NTSLPAEEAN GSLSEEEANG 120
PELGSGKAME DTSGEPAAED EGDTAWNYSF SQLPRFLSGS WSEFSTQPEN FLKGCKWAPD 180
GSCILTNSAD NILRIYNLPP ELYHEGEQVE YAEMVPVLRM VEGDTIYDYC WYSLMSSAQP 240
DTSYVASSSR ENPIHIWDAF TGELRASFRA YNHLDELTAA HSLCFSPDGS QLFCGFNRTV 300
RVFSTARPGR DCEVRATFAK KQGQSGIISC IAFSPAQPLY ACGSYGRSLG LYAWDDGSPL 360
ALLGGHQGGI THLCFHPDGN RFFSGARKDA ELLCWDLRQS GYPLWSLGRE VTTNQRIYFD 420
LDPTGQFLVS GSTSGAVSVW DTDGPGNDGK PEPVLSFLPQ KDCTNGVSLH PSLPLLATAS 480
GQRVFPEPTE SGDEGEELGL PLLSTRHVHL ECRLQLWWCG GAPDSSIPDD HQGEKGQGGT 540
EGGVGELI 548 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |