CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014103
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Myomegalin 
Protein Synonyms/Alias
 Cardiomyopathy-associated protein 2; Phosphodiesterase 4D-interacting protein 
Gene Name
 PDE4DIP 
Gene Synonyms/Alias
 CMYA2; KIAA0454; KIAA0477; MMGL 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
86LQKLLLEKDRLKFCIubiquitination[1]
639ANEMLLEKLRQRIHDubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
 May function as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes (By similarity). 
Sequence Annotation
 DOMAIN 1551 1642 NBPF.
 MOD_RES 704 704 Phosphothreonine.  
Keyword
 Alternative splicing; Chromosomal rearrangement; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Golgi apparatus; Nucleus; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2346 AA 
Protein Sequence
MKEICRICAR ELCGNQRRWI FHTASKLNLQ VLLSHVLGKD VPRDGKAEFA CSKCAFMLDR 60
IYRFDTVIAR IEALSIERLQ KLLLEKDRLK FCIASMYRKN NDDSGAEIKA GNGTVDMSVL 120
PDARYSALLQ EDFAYSGFEC WVENEDQIQE PHSCHGSEGP GNRPRRCRGC AALRVADSDY 180
EAICKVPRKV ARSISCGPSS RWSTSICTEE PALSEVGPPD LASTKVPPDG ESMEEETPGS 240
SVESLDASVQ ASPPQQKDEE TERSAKELGK CDCCSDDQAP QHGCNHKLEL ALSMIKGLDY 300
KPIQSPRGSR LPIPVKSSLP GAKPGPSMTD GVSSGFLNRS LKPLYKTPVS YPLELSDLQE 360
LWDDLCEDYL PLRVQPMTEE LLKQQKLNSH ETTITQQSVS DSHLAELQEK IQQTEATNKI 420
LQEKLNEMSY ELKCAQESSQ KQDGTIQNLK ETLKSRERET EELYQVIEGQ NDTMAKLREM 480
LHQSQLGQLH SSEGTSPAQQ QVALLDLQSA LFCSQLEIQK LQRVVRQKER QLADAKQCVQ 540
FVEAAAHESE QQKEASWKHN QELRKALQQL QEELQNKSQQ LRAWEAEKYN EIRTQEQNIQ 600
HLNHSLSHKE QLLQEFRELL QYRDNSDKTL EANEMLLEKL RQRIHDKAVA LERAIDEKFS 660
ALEEKEKELR QLRLAVRERD HDLERLRDVL SSNEATMQSM ESLLRAKGLE VEQLSTTCQN 720
LQWLKEEMET KFSRWQKEQE SIIQQLQTSL HDRNKEVEDL SATLLCKLGP GQSEIAEELC 780
QRLQRKERML QDLLSDRNKQ VLEHEMEIQG LLQSVSTREQ ESQAAAEKLV QALMERNSEL 840
QALRQYLGGR DSLMSQAPIS NQQAEVTPTG CLGKQTDQGS MQIPSRDDST SLTAKEDVSI 900
PRSTLGDLDT VAGLEKELSN AKEELELMAK KERESQMELS ALQSMMAVQE EELQVQAADM 960
ESLTRNIQIK EDLIKDLQMQ LVDPEDIPAM ERLTQEVLLL REKVASVESQ GQEISGNRRQ 1020
QLLLMLEGLV DERSRLNEAL QAERQLYSSL VKFHAHPESS ERDRTLQVEL EGAQVLRSRL 1080
EEVLGRSLER LNRLETLAAI GGAAAGDDTE DTSTEFTDSI EEEAAHHSHQ QL 1132 
Gene Ontology
 GO:0005813; C:centrosome; IDA:UniProtKB.
 GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
 GO:0030016; C:myofibril; ISS:UniProtKB.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0019899; F:enzyme binding; ISS:UniProtKB.
 GO:0043623; P:cellular protein complex assembly; ISS:UniProtKB. 
Interpro
 IPR010630; NBPF_dom.
 IPR012943; Spindle_assoc. 
Pfam
 PF06758; DUF1220
 PF07989; Microtub_assoc 
SMART
  
PROSITE
 PS51316; NBPF 
PRINTS