UniProt Accession

 SRS10_MOUSE; Q9R0U0; B1AV44; B1AV45; O70307; O88468; Q3TGW7; Q8CFZ1; Q9R0T9 

Genbank Protein ID

 AF042383; AB015894; AB015895; AF060490; AK014345; AK168524; AK168558; AL672076; AL672076; BC037591; BC043060; BC083082 

Genbank Nucleotide ID

 AAC70916.1; BAA35092.1; BAA35093.1; AAC26715.1; BAB29286.1; BAE40403.1; BAE40431.1; CAM15892.1; CAM15893.1; AAH37591.1; AAH43060.1; AAH83082.1 

Protein Name

 Serine/arginine-rich splicing factor 10 

Protein Synonyms/Alias

 FUS-interacting serine-arginine-rich protein 1; Neural-salient serine/arginine-rich protein; Neural-specific SR protein; Splicing factor, arginine/serine-rich 13A; TLS-associated protein with Ser-Arg repeats; TASR; TLS-associated protein with SR repeats; TLS-associated serine-arginine protein; TLS-associated SR protein 

Gene Name

 Srsf10 

Gene Synonyms/Alias

 Fusip1; Nssr; Sfrs13a; Srsf13a 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
214	GTSKTDSKTHYKSGS	acetylation	[1]

Reference

 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing. Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70. Required for splicing repression in M-phase cells and after heat shock (By similarity). May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator. 

Sequence Annotation

 DOMAIN 10 88 RRM.
 MOD_RES 106 106 Phosphoserine (By similarity).
 MOD_RES 108 108 Phosphoserine (By similarity).
 MOD_RES 119 119 Phosphoserine.
 MOD_RES 121 121 Phosphoserine.
 MOD_RES 129 129 Phosphoserine (By similarity).
 MOD_RES 131 131 Phosphoserine.
 MOD_RES 133 133 Phosphoserine.
 MOD_RES 158 158 Phosphoserine.
 MOD_RES 160 160 Phosphoserine.  

Keyword

 Alternative splicing; Complete proteome; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; RNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 262 AA 

Protein Sequence

Gene Ontology

 GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
 GO:0005654; C:nucleoplasm; IDA:UniProtKB.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; NAS:UniProtKB.
 GO:0051082; F:unfolded protein binding; NAS:UniProtKB.
 GO:0006406; P:mRNA export from nucleus; NAS:UniProtKB.
 GO:0006376; P:mRNA splice site selection; ISS:UniProtKB.
 GO:0048025; P:negative regulation of mRNA splicing, via spliceosome; IDA:UniProtKB.
 GO:0006355; P:regulation of transcription, DNA-dependent; NAS:UniProtKB. 

Interpro

 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 

Pfam

 PF00076; RRM_1 

SMART

 SM00360; RRM 

PROSITE

 PS50102; RRM 

PRINTS