CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022895
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 GTPase IMAP family member 2 
Protein Synonyms/Alias
 Immunity-associated protein 2; hIMAP2 
Gene Name
 GIMAP2 
Gene Synonyms/Alias
 IMAP2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
14SHWGPHAKGQCASRSubiquitination[1]
51RKQAFESKLGSQTLTubiquitination[1]
59LGSQTLTKTCSKSQGubiquitination[1]
63TLTKTCSKSQGSWGNubiquitination[1]
170SDNKALSKLVAACGGubiquitination[1, 2]
226YSLIQRSKCGPVGSDubiquitination[1]
237VGSDERVKEFKQSLIubiquitination[1, 2]
240DERVKEFKQSLIKYMubiquitination[1]
263LAEANCLKGALIKTQubiquitination[1, 2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
 The heterodimer formed by GIMAP2 and GIMAP7 has GTPase activity. In contrast, GIMAP2 has no GTPase activity by itself. 
Sequence Annotation
 NP_BIND 29 37 GTP.
 NP_BIND 57 58 GTP.
 NP_BIND 147 149 GTP.
 BINDING 50 50 GTP.
 BINDING 184 184 GTP.  
Keyword
 3D-structure; Complete proteome; Cytoplasm; GTP-binding; Lipid droplet; Membrane; Nucleotide-binding; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 337 AA 
Protein Sequence
MDQNEHSHWG PHAKGQCASR SELRIILVGK TGTGKSAAGN SILRKQAFES KLGSQTLTKT 60
CSKSQGSWGN REIVIIDTPD MFSWKDHCEA LYKEVQRCYL LSAPGPHVLL LVTQLGRYTS 120
QDQQAAQRVK EIFGEDAMGH TIVLFTHKED LNGGSLMDYM HDSDNKALSK LVAACGGRIC 180
AFNNRAEGSN QDDQVKELMD CIEDLLMEKN GDHYTNGLYS LIQRSKCGPV GSDERVKEFK 240
QSLIKYMETQ RSYTALAEAN CLKGALIKTQ LCVLFCIQLF LRLIILWLCI LHSMCNLFCC 300
LLFSMCNLFC SLLFIIPKKL MIFLRTVIRL ERKTPRL 337 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005811; C:lipid particle; IDA:UniProtKB.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW. 
Interpro
 IPR006703; AIG1.
 IPR027417; P-loop_NTPase. 
Pfam
 PF04548; AIG1 
SMART
  
PROSITE
  
PRINTS