CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037399
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Peptidyl-prolyl cis-trans isomerase 
Protein Synonyms/Alias
  
Gene Name
 PPIE 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
161NHNGTGGKSIYGKKFacetylation[1]
161NHNGTGGKSIYGKKFubiquitination[2]
167GKSIYGKKFDDENFIubiquitination[3]
203QFFLTCDKTDWLDGKmethylation[4]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510] 
Functional Description
 PPIases accelerate the folding of proteins (By similarity). 
Sequence Annotation
  
Keyword
 Complete proteome; Isomerase; Reference proteome; Rotamase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 250 AA 
Protein Sequence
MATTKRVLYV GGLAEEVDDK VLHAAFIPFG DITDIQIPLD YETVWSDDDW LKKFSGKTLE 60
ENKEEEGSEP PKAETQEGEP IAKKARSNPQ VYMDIKIGNK PAGRIQMLLR SDVVPMTAEN 120
FRCLCTHEKG FGFKGSSFHR IIPQFMCQGG DFTNHNGTGG KSIYGKKFDD ENFILKHTGP 180
GLLSMANSGP NTNGSQFFLT CDKTDWLDGK HVVFGEVTEG LDVLRQIEAQ GSKDGKPKQK 240
VIIADCGEYV 250 
Gene Ontology
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:UniProtKB-KW.
 GO:0006457; P:protein folding; IEA:UniProtKB-KW.
 GO:0000413; P:protein peptidyl-prolyl isomerization; IEA:GOC. 
Interpro
 IPR002130; Cyclophilin-like_PPIase_dom.
 IPR020892; Cyclophilin-type_PPIase_CS.
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 
Pfam
 PF00160; Pro_isomerase
 PF00076; RRM_1 
SMART
 SM00360; RRM 
PROSITE
 PS00170; CSA_PPIASE_1
 PS50072; CSA_PPIASE_2 
PRINTS
 PR00153; CSAPPISMRASE.