CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000365
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger and BTB domain-containing protein 5 
Protein Synonyms/Alias
  
Gene Name
 ZBTB5 
Gene Synonyms/Alias
 KIAA0354 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
239FFSPDSLKIVDNPKAubiquitination[1, 2, 3]
322PEVGLGEKEHMRVVVubiquitination[2, 3]
415SISNFLNKSRGNNFTubiquitination[2, 4]
597DVLSKCKKALSEHNVubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
 May be involved in transcriptional regulation. 
Sequence Annotation
 DOMAIN 24 93 BTB.
 ZN_FING 613 635 C2H2-type 1.
 ZN_FING 641 664 C2H2-type 2; atypical.
 MOD_RES 371 371 Phosphoserine.  
Keyword
 Complete proteome; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 677 AA 
Protein Sequence
MDFPGHFEQI FQQLNYQRLH GQLCDCVIVV GNRHFKAHRS VLAACSTHFR ALFSVAEGDQ 60
TMNMIQLDSE VVTAEAFAAL IDMMYTSTLM LGESNVMDVL LAASHLHLNS VVKACKHYLT 120
TRTLPMSPPS ERVQEQSARM QRSFMLQQLG LSIVSSALNS SQNGEEQPAP MSSSMRSNLD 180
QRTPFPMRRL HKRKQSAEER ARQRLRPSID ESAISDVTPE NGPSGVHSRE EFFSPDSLKI 240
VDNPKADGMT DNQEDSAIMF DQSFGTQEDA QVPSQSDNSA GNMAQLSMAS RATQVETSFD 300
QEAAPEKSSF QCENPEVGLG EKEHMRVVVK SEPLSSPEPQ DEVSDVTSQA EGSESVEVEG 360
VVVSAEKIDL SPESSDRSFS DPQSSTDRVG DIHILEVTNN LEHKSTFSIS NFLNKSRGNN 420
FTANQNNDDN IPNTTSDCRL ESEAPYLLSP EAGPAGGPSS APGSHVENPF SEPADSHFVR 480
PMQEVMGLPC VQTSGYQGGE QFGMDFSRSG LGLHSSFSRV MIGSPRGGAS NFPYYRRIAP 540
KMPVVTSVRS SQIPENSTSS QLMMNGATSS FENGHPSQPG PPQLTRASAD VLSKCKKALS 600
EHNVLVVEGA RKYACKICCK TFLTLTDCKK HIRVHTGEKP YACLKCGKRF SQSSHLYKHS 660
KTTCLRWQSS NLPSTLL 677 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR000210; BTB/POZ-like.
 IPR011333; BTB/POZ_fold.
 IPR013069; BTB_POZ.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF00651; BTB 
SMART
 SM00225; BTB
 SM00355; ZnF_C2H2 
PROSITE
 PS50097; BTB
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS