UniProt Accession

 GNAL_MOUSE; Q8CGK7; Q61020; Q61589 

Genbank Protein ID

 AY179169; U38503; M57635 

Genbank Nucleotide ID

 AAO03564.1; AAB01734.1; AAA63300.1 

Protein Name

 Guanine nucleotide-binding protein G(olf) subunit alpha 

Protein Synonyms/Alias

 Adenylate cyclase-stimulating G alpha protein, olfactory type 

Gene Name

 Gnal 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
9	GCLGNSSKTAEDQGV	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(olf) alpha mediates signal transduction within the olfactory neuroepithelium and the basal ganglia. May be involved in some aspect of visual transduction, and in mediating the effect of one or more hormones/neurotransmitters (By similarity). 

Sequence Annotation

 NP_BIND 49 56 GTP (By similarity).
 NP_BIND 185 191 GTP (By similarity).
 NP_BIND 210 214 GTP (By similarity).
 NP_BIND 279 282 GTP (By similarity).
 METAL 56 56 Magnesium (By similarity).
 METAL 191 191 Magnesium (By similarity).
 BINDING 353 353 GTP; via amide nitrogen (By similarity).
 LIPID 2 2 N-palmitoyl glycine (By similarity).
 LIPID 3 3 S-palmitoyl cysteine (By similarity).  

Keyword

 Complete proteome; Direct protein sequencing; GTP-binding; Lipoprotein; Magnesium; Metal-binding; Nucleotide-binding; Palmitate; Reference proteome; Transducer. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 381 AA 

Protein Sequence

Gene Ontology

 GO:0005834; C:heterotrimeric G-protein complex; ISA:MGI.
 GO:0004016; F:adenylate cyclase activity; IBA:RefGenome.
 GO:0031683; F:G-protein beta/gamma-subunit complex binding; IBA:RefGenome.
 GO:0001664; F:G-protein coupled receptor binding; IBA:RefGenome.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; ISA:MGI.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004871; F:signal transducer activity; IBA:RefGenome.
 GO:0007190; P:activation of adenylate cyclase activity; IDA:MGI.
 GO:0007191; P:adenylate cyclase-activating dopamine receptor signaling pathway; IGI:MGI.
 GO:0001975; P:response to amphetamine; IMP:MGI.
 GO:0031000; P:response to caffeine; IMP:MGI.
 GO:0007608; P:sensory perception of smell; IMP:MGI. 

Interpro

 IPR000367; Gprotein_alpha_S.
 IPR001019; Gprotein_alpha_su.
 IPR011025; GproteinA_insert.
 IPR027417; P-loop_NTPase. 

Pfam

 PF00503; G-alpha 

SMART

 SM00275; G_alpha 

PROSITE

  

PRINTS

 PR00318; GPROTEINA.
 PR00443; GPROTEINAS.