UniProt Accession

 DRG2_MOUSE; Q9QXB9; Q5SX94 

Genbank Protein ID

 AJ243590; AL596090; BC082564 

Genbank Nucleotide ID

 CAB65258.1; CAI24081.1; AAH82564.1 

Protein Name

 Developmentally-regulated GTP-binding protein 2 

Protein Synonyms/Alias

 DRG-2 

Gene Name

 Drg2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
6	**MGILEKISEIEKE	acetylation	[1]
12	EKISEIEKEIARTQK	acetylation	[1]
161	VQRSLLEKELESVGI	ubiquitination	[2]
174	GIRLNKHKPNIYFKP	acetylation	[3]
174	GIRLNKHKPNIYFKP	succinylation	[3]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 May play a role in cell proliferation, differentiation and death. 

Sequence Annotation

 DOMAIN 74 172 G.
 NP_BIND 69 76 GTP (By similarity).
 NP_BIND 115 119 GTP (By similarity).
 NP_BIND 246 249 GTP (By similarity).
 MOD_RES 199 199 Phosphoserine.  

Keyword

 Complete proteome; Cytoplasm; GTP-binding; Nucleotide-binding; Phosphoprotein; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 364 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW. 

Interpro

 IPR006074; GTP1-OBG_CS.
 IPR006073; GTP_binding_domain.
 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR004095; TGS.
 IPR012676; TGS-like. 

Pfam

 PF01926; MMR_HSR1
 PF02824; TGS 

SMART

  

PROSITE

 PS00905; GTP1_OBG 

PRINTS

 PR00326; GTP1OBG.