UniProt Accession

 D6RCP9_HUMAN; D6RCP9 

Genbank Protein ID

 AC093851 

Genbank Nucleotide ID

  

Protein Name

 Deoxycytidine kinase 

Protein Synonyms/Alias

  

Gene Name

 DCK 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
23	SEGTRIKKISIEGNI	ubiquitination	[1]
34	EGNIAAGKSTFVNIL	ubiquitination	[1, 2]
76	EELTMSQKNGGNVLQ	ubiquitination	[1]
88	VLQMMYEKPERWSFT	ubiquitination	[1]
115	QLASLNGKLKDAEKP	ubiquitination	[1]
117	ASLNGKLKDAEKPVL	ubiquitination	[1, 3, 4, 5]
121	GKLKDAEKPVLFFER	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.
 Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML.
 Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. [PMID: 21139048]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

  

Sequence Annotation

 ACT_SITE 127 127 Proton acceptor (By similarity).
 BINDING 53 53 Substrate (By similarity).
 BINDING 86 86 Substrate (By similarity).
 BINDING 97 97 Substrate (By similarity).
 BINDING 128 128 Substrate (By similarity).
 BINDING 133 133 Substrate (By similarity).
 BINDING 183 183 Substrate (By similarity).  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 199 AA 

Protein Sequence

Gene Ontology

 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IEA:InterPro.
 GO:0006139; P:nucleobase-containing compound metabolic process; IEA:InterPro. 

Interpro

 IPR002624; Deoxynucleoside_kinase.
 IPR027417; P-loop_NTPase. 

Pfam

 PF01712; dNK 

SMART

  

PROSITE

  

PRINTS