UniProt Accession

 B3GT6_HUMAN; Q96L58; Q5T7M5 

Genbank Protein ID

 AY050570; AL162741 

Genbank Nucleotide ID

 AAL11442.1; CAI23255.1 

Protein Name

 Beta-1,3-galactosyltransferase 6 

Protein Synonyms/Alias

 Beta-1,3-GalTase 6; Beta3Gal-T6; Beta3GalT6; GAG GalTII; Galactosyltransferase II; Galactosylxylosylprotein 3-beta-galactosyltransferase; UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6 

Gene Name

 B3GALT6 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
280	NQYLVTHKQSLEDML	ubiquitination	[1]
289	SLEDMLEKHATLARE	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-linked galactose residue. Has a preference for galactose-beta-1,4-xylose that is found in the linker region of glycosaminoglycans, such as heparan sulfate and chondroitin sulfate. Has no activity towards substrates with terminal glucosamine or galactosamine residues. 

Sequence Annotation

 CARBOHYD 131 131 N-linked (GlcNAc...) (Potential).  

Keyword

 Complete proteome; Glycoprotein; Glycosyltransferase; Golgi apparatus; Manganese; Membrane; Polymorphism; Reference proteome; Signal-anchor; Transferase; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 329 AA 

Protein Sequence

Gene Ontology

 GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.
 GO:0005797; C:Golgi medial cisterna; IDA:UniProtKB.
 GO:0000139; C:Golgi membrane; TAS:Reactome.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0047220; F:galactosylxylosylprotein 3-beta-galactosyltransferase activity; IEA:EC.
 GO:0008499; F:UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity; IEA:Compara.
 GO:0035250; F:UDP-galactosyltransferase activity; IDA:UniProtKB.
 GO:0005975; P:carbohydrate metabolic process; TAS:Reactome.
 GO:0030206; P:chondroitin sulfate biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0030204; P:chondroitin sulfate metabolic process; TAS:Reactome.
 GO:0006024; P:glycosaminoglycan biosynthetic process; IMP:UniProtKB.
 GO:0015012; P:heparan sulfate proteoglycan biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0006486; P:protein glycosylation; IEA:InterPro. 

Interpro

 IPR002659; Glyco_trans_31. 

Pfam

 PF01762; Galactosyl_T 

SMART

  

PROSITE

  

PRINTS