| Tag | Content |
|---|
| CPLM ID | CPLM-013022 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | F-box only protein 31 |
Protein Synonyms/Alias | |
Gene Name | Fbxo31 |
Gene Synonyms/Alias | MNCb-2609 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 215 | KRDEFSTKCNQTDHH | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest (By similarity). |
Sequence Annotation | DOMAIN 50 96 F-box.
MOD_RES 33 33 Phosphoserine.
MOD_RES 37 37 Phosphothreonine.
MOD_RES 264 264 Phosphoserine; by ATM (By similarity). |
Keyword | Cell cycle; Complete proteome; DNA damage; Phosphoprotein; Reference proteome; Ubl conjugation pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 507 AA |
Protein Sequence | MAVCARLCGV GPARGCRRRQ QRRGPAETAA ADSEADTDPE EERIEAGPAR CSLLELPPEL 60
LVEIFASLPG TDLPSLAQVC SRFRRILHTD TIWRRRCREE YGVCENLRKL EITGVSCRDV 120
YAKLLHRYRH ILGLWQPDIG PYGGLLNVVV DGLFIIGWMY LPPHDPHVGD PMRFKPLFRI 180
HLMERKSATV ECMYGHKGPH NGHIQIVKRD EFSTKCNQTD HHRMSGGRQE EFRTWLREEW 240
GRTLEDIFHE HMQELILMKF IYTSQYDNCL TYRRIYLPPS HPDDLIKPGL FKGTYGSHGL 300
EIVMLSFHGS RARGTKITGD PNIPAGQQTV EIDLQRRIQL PDVENLRNFN ELSRIVLEVR 360
EQVRQEQEAG EGAAPPREPS AKAADGPPAK DGKEPGGGAE AAEQSASSGQ GQPFVLPVGV 420
SSRNEDYPRT CRLCFYGTGL IAGHGFTSPE RTPGVFVLFD EDRFGFLWLE LKSFSLYSRV 480
QATFQNAAAP SPQAFDEMLR NIQSLTS 507 |
Gene Ontology | GO:0019005; C:SCF ubiquitin ligase complex; ISS:UniProtKB. GO:0008054; P:cyclin catabolic process; ISS:UniProtKB. GO:0031571; P:mitotic G1 DNA damage checkpoint; ISS:UniProtKB. GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway. GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |