UniProt Accession

 A6NF48_HUMAN; A6NF48 

Genbank Protein ID

 AC104461 

Genbank Nucleotide ID

  

Protein Name

 Zinc finger protein 281 

Protein Synonyms/Alias

  

Gene Name

 ZNF281 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
66	APDMTFKKEPAASAA	ubiquitination	[1, 2]
177	HHGTEEPKQDTNVKK	ubiquitination	[2]
279	EKIHSREKPFGCDQC	ubiquitination	[1, 2]
293	CSMKFIQKYHMERHK	ubiquitination	[1, 2]
307	KRTHSGEKPYKCDTC	ubiquitination	[1]
310	HSGEKPYKCDTCQQY	ubiquitination	[1, 2]
337	TCGEVIVKGATSAEP	ubiquitination	[1, 2]
373	SRRKTKSKSIAIENK	ubiquitination	[2]
380	KSIAIENKEQKTGKT	ubiquitination	[2]
383	AIENKEQKTGKTNES	ubiquitination	[1]
437	IFKKGSRKNTDKNYL	ubiquitination	[2]
441	GSRKNTDKNYLNFVS	ubiquitination	[1, 2]
462	GQKSLSGKPSGSLGI	ubiquitination	[1, 2]
503	DDAMQFSKKRRYLPT	ubiquitination	[1, 2, 3, 4]
504	DAMQFSKKRRYLPTA	ubiquitination	[2]
563	EIKSCHDKSGIPDEV	ubiquitination	[1, 2]
581	ILDQYSNKSESQKED	ubiquitination	[1, 2, 4, 5]
586	SNKSESQKEDPFNIA	ubiquitination	[1, 2, 3, 4, 5]
625	TQTPSNDKASMLQEY	ubiquitination	[1, 2, 3, 5]
634	SMLQEYSKYLQQAFE	ubiquitination	[1, 2, 3, 4]
751	AFQSSSQKLTSQKEQ	acetylation	[6]
751	AFQSSSQKLTSQKEQ	ubiquitination	[1, 2, 3, 4]
759	LTSQKEQKNLESSTG	ubiquitination	[2, 3]
782	ASQIDPQKDIEPRTT	ubiquitination	[1, 2, 4]
804	QAFGSQFKSGSRVPM	ubiquitination	[1, 2, 3, 4]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [6] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 859 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IDA:HPA.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 

Interpro

 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 

Pfam

  

SMART

 SM00355; ZnF_C2H2 

PROSITE

 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 

PRINTS