UniProt Accession

 Q5T5C7_HUMAN; Q5T5C7 

Genbank Protein ID

 AL356389 

Genbank Nucleotide ID

  

Protein Name

 Serine--tRNA ligase, cytoplasmic 

Protein Synonyms/Alias

  

Gene Name

 SARS 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
12	LDLFRVDKGGDPALI	ubiquitination	[1]
28	ETQEKRFKDPGLVDQ	ubiquitination	[1]
55	FRADNLNKLKNLCSK	ubiquitination	[1]
62	KLKNLCSKTIGEKMK	ubiquitination	[1]
70	TIGEKMKKKEPVGDD	ubiquitination	[1]
71	IGEKMKKKEPVGDDE	ubiquitination	[1]
116	LIDEAILKCDAERIK	ubiquitination	[1]
123	KCDAERIKLEAERFE	ubiquitination	[1]
154	NDEDVDNKVERIWGD	ubiquitination	[1]
231	YTPFFMRKEVMQEVA	ubiquitination	[1]
249	QFDEELYKVIGKGSE	ubiquitination	[1]
266	DDNSYDEKYLIATSE	ubiquitination	[1]
293	RPEDLPIKYAGLSTC	ubiquitination	[1]
376	LNHAASKKLDLEAWF	ubiquitination	[1, 2, 3]
470	LENYQTEKGITVPEK	ubiquitination	[1]
477	KGITVPEKLKEFMPP	ubiquitination	[1]
494	QELIPFVKPAPIEQE	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 536 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0004828; F:serine-tRNA ligase activity; IEA:InterPro.
 GO:0006434; P:seryl-tRNA aminoacylation; IEA:InterPro. 

Interpro

 IPR002314; aa-tRNA-synt_IIb_cons-dom.
 IPR006195; aa-tRNA-synth_II.
 IPR002317; Ser-tRNA-ligase_type_1.
 IPR015866; Ser-tRNA-synth_1_N.
 IPR010978; tRNA-bd_arm. 

Pfam

 PF02403; Seryl_tRNA_N
 PF00587; tRNA-synt_2b 

SMART

  

PROSITE

 PS50862; AA_TRNA_LIGASE_II 

PRINTS

 PR00981; TRNASYNTHSER.