Tag | Content |
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CPLM ID | CPLM-005212 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Troponin I, cardiac muscle |
Protein Synonyms/Alias | Cardiac troponin I |
Gene Name | Tnni3 |
Gene Synonyms/Alias | Ctni; Tni |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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51 | ASRKLQLKTLMLQIA | acetylation | [1] | 59 | TLMLQIAKQEMEREA | acetylation | [1] | 107 | QLHARVDKVDEERYD | acetylation | [1] | 121 | DVEAKVTKNITEIAD | acetylation | [1] | 132 | EIADLTQKIYDLRGK | acetylation | [1] | 141 | YDLRGKFKRPTLRRV | acetylation | [1] | 165 | ALLGTRAKESLDLRA | acetylation | [1] | 178 | RAHLKQVKKEDIEKE | acetylation | [1] | 184 | VKKEDIEKENREVGD | acetylation | [1] | 194 | REVGDWRKNIDALSG | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. |
Sequence Annotation | REGION 33 80 Involved in binding TNC. REGION 130 151 Involved in binding TNC and actin. MOD_RES 2 2 N-acetylalanine (By similarity). MOD_RES 5 5 Phosphoserine (By similarity). MOD_RES 6 6 Phosphoserine (By similarity). MOD_RES 23 23 Phosphoserine; by PKA and PKD/PRKD1 (By MOD_RES 24 24 Phosphoserine; by PKA and PKD/PRKD1 (By MOD_RES 27 27 Phosphotyrosine (By similarity). MOD_RES 32 32 Phosphothreonine; by STK4/MST1 (By MOD_RES 43 43 Phosphoserine; by PKC/PRKCE (By MOD_RES 45 45 Phosphoserine; by PKC/PRKCE (By MOD_RES 52 52 Phosphothreonine; by STK4/MST1 (By MOD_RES 78 78 Phosphoserine (By similarity). MOD_RES 79 79 Phosphothreonine (By similarity). MOD_RES 130 130 Phosphothreonine; by STK4/MST1 (By MOD_RES 144 144 Phosphothreonine; by STK4/MST1 (By MOD_RES 151 151 Phosphoserine; by PAK3 (By similarity). MOD_RES 167 167 Phosphoserine (By similarity). MOD_RES 200 200 Phosphoserine (By similarity). |
Keyword | Acetylation; Actin-binding; Calcium; Complete proteome; Metal-binding; Muscle protein; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 211 AA |
Protein Sequence | MADESSDAAG EPQPAPAPVR RRSSANYRAY ATEPHAKKKS KISASRKLQL KTLMLQIAKQ 60 EMEREAEERR GEKGRVLSTR CQPLVLDGLG FEELQDLCRQ LHARVDKVDE ERYDVEAKVT 120 KNITEIADLT QKIYDLRGKF KRPTLRRVRI SADAMMQALL GTRAKESLDL RAHLKQVKKE 180 DIEKENREVG DWRKNIDALS GMEGRKKKFE G 211 |
Gene Ontology | GO:0005861; C:troponin complex; TAS:RGD. GO:0019855; F:calcium channel inhibitor activity; IEA:Compara. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0060048; P:cardiac muscle contraction; IDA:RGD. GO:0006874; P:cellular calcium ion homeostasis; IEA:Compara. GO:0032780; P:negative regulation of ATPase activity; IEA:Compara. GO:0006940; P:regulation of smooth muscle contraction; IMP:RGD. GO:0001980; P:regulation of systemic arterial blood pressure by ischemic conditions; IEA:Compara. GO:0001570; P:vasculogenesis; IEA:Compara. GO:0055010; P:ventricular cardiac muscle tissue morphogenesis; IEA:Compara. |
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