CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017968
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 TBC1 domain family member 16 
Protein Synonyms/Alias
  
Gene Name
 TBC1D16 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
394HPEESMYKRLGVSAWubiquitination[1]
490NVQFTVDKDVVRTDRubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 May act as a GTPase-activating protein for Rab family protein(s). 
Sequence Annotation
 DOMAIN 425 635 Rab-GAP TBC.  
Keyword
 Complete proteome; GTPase activation; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 767 AA 
Protein Sequence
MSLGRLLRRA SSKASDLLTL TPGGSGSGSP SVLDGEIIYS KNNVCVHPPE GLQGLGEHHP 60
GYLCLYMEKD EMLGATLILA WVPNSRIQRQ DEEALRYITP ESSPVRKAPR PRGRRTRSSG 120
ASHQPSPTEL RPTLTPKDED ILVVAQSVPD RMLASPAPED EEKLAQGLGV DGAQPASQPA 180
CSPSGILSTV SPQDVTEEGR EPRPEAGEED GSLELSAEGV SRDSSFDSDS DTFSSPFCLS 240
PISAALAESR GSVFLESDSS PPSSSDAGLR FPDSNGLLQT PRWDEPQRVC ALEQICGVFR 300
VDLGHMRSLR LFFSDEACTS GQLVVASRES QYKVFHFHHG GLDKLSDVFQ QWKYCTEMQL 360
KDQQVAPDKT CMQFSIRRPK LPSSETHPEE SMYKRLGVSA WLNHLNELGQ VEEEYKLRKA 420
IFFGGIDVSI RGEVWPFLLR YYSHESTSEE REALRLQKRK EYSEIQQKRL SMTPEEHRAF 480
WRNVQFTVDK DVVRTDRNNQ FFRGEDNPNV ESMRRILLNY AVYNPAVGYS QGMSDLVAPI 540
LAEVLDESDT FWCFVGLMQN TIFVSSPRDE DMEKQLLYLR ELLRLTHVRF YQHLVSLGED 600
GLQMLFCHRW LLLCFKREFP EAEALRIWEA CWAHYQTDYF HLFICVAIVA IYGDDVIEQQ 660
LATDQMLLHF GNLAMHMNGE LVLRKARSLL YQFRLLPRIP CSLHDLCKLC GSGMWDSGSM 720
PAVECTGHHP GSESCPYGGT VEMPSPKSLR EGKKGPKTPQ DGFGFRR 767 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005097; F:Rab GTPase activator activity; IEA:InterPro.
 GO:0032851; P:positive regulation of Rab GTPase activity; IEA:GOC. 
Interpro
 IPR000195; Rab-GTPase-TBC_dom. 
Pfam
 PF00566; RabGAP-TBC 
SMART
 SM00164; TBC 
PROSITE
 PS50086; TBC_RABGAP 
PRINTS