CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025849
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ATP-binding cassette, sub-family C, member 3 isoform MRP3 variant 
Protein Synonyms/Alias
  
Gene Name
  
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
518AWEPSFLKQVEGIRQubiquitination[1]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Nucleotide-binding; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1533 AA 
Protein Sequence
QPRLGPMDAL CGSGELGSKF WDSNLSVHTE NPDLTPCFQN SLLAWVPCIY LWVALPCYLL 60
YLRHHCRGYI ILSHLSKLKM VLGVLLWCVS WADLFYSFHG LVHGRAPAPV FFVTPLVVGV 120
TMLLATLLIQ YERLQGVQSS GVLIIFWFLC VVCAIVPFRS KILLAKAEGE ISDPFRFTTF 180
YIHFALVLSA LILACFREKP PFFSAKNVDP NPYPETSAGF LSRLFFWWFT KMAIYGYRHP 240
LEEKDLWSLK EEDRSQMVVQ QLLEAWRKQE KQTARHKASA APGKNASGED EVLLGARPRP 300
RKPSFLKALL ATFGSSFLIS ACFKLIQDLL SFINPQLLSI LIRFISNPMA PSWWGFLVAG 360
LMFLCSMMQS LILQHYYHYI FVTGVKFRTG IMGVIYRKAL VITNSVKRAS TVGEIVNLMS 420
VDAQRFMDLA PFLNLLWSAP LQIILAIYFL WQNLGPSVLA GVAFMVLLIP LNGAVAVKMR 480
AFQVKQMKLK DSRIKLMSEI LNGIKVLKLY AWEPSFLKQV EGIRQGELQL LRTAAYLHTT 540
TTFTWMCSPF LVTLITLWVY VYVDPNNVLD AEKAFVSVSL FNILRLPLNM LPQLISNLTQ 600
ASVSLKRIQQ FLSQEELDPQ SVERKTISPG YAITIHSGTF TWAQDLPPTL HSLDIQVPKG 660
ALVAVVGPVG CGKSSLVSAL LGEMEKLEGK VHMKGSVAYV PQQAWIQNCT LQENVLFGKA 720
LNPKRYQQTL EACALLADLE MLPGGDQTEI GEKGINLSGG QRQRVSLARA VYSDADIFLL 780
DDPLSAVDSH VAKHIFDHVI GPEGVLAGKT RVLVTHGISF LPQTDFIIVL ADGQVSEMGP 840
YPALLQRNGS FANFLCNYAP DEDQGHLEDS WTALEGAEDK EALLIEDTLS NHTDLTDNDP 900
VTYVVQKQFM RQLSALSSDG EGQGRPVPRR HLGPSEKVQV TEAKADGALT QEEKAAIGTV 960
ELSVFWDYAK AVGLCTTLAI CLLYVGQSAA AIGANVWLSA WTNDAMADSR QNNTSLRLGV 1020
YAALGILQGF LVMLAAMAMA AGGIQAARVL HQALPHNKIR SPQSFFDTTP SGRILNCFSK 1080
DIYVVDEVLA PVILMLLNSF FNAISTLVVI MASTPLFTVV ILPLAVLYTL VQRFYAATSR 1140
QLKRLESVSR SPIYSHFSET VTGASVIRAY NRSRDFEIIS DTKVDANQRS CYPYIISNRW 1200
LSIGVEFVGN CVVLFAALFA VIGRSSLNPG LVGLSVSYSL QVTFALNWMI RMMSDLESNI 1260
VAVERVKEYS KTETEAPWVV EGSRPPEGWP PRGEVEFRNY SVRYRPGLDL VLRDLSLHVH 1320
GGEKVGIVGR TGAGKSSMTL CLFRILEAAK GEIRIDGLNV ADIGLHDLRS QLTIIPQDPI 1380
LFSGTLRMNL DPFGSYSEED IWWALELSHL HTFVSSQPAG LDFQCSEGGE NLSVGQRQLV 1440
CLARALLRKS RILVLDEATA AIDLETDNLI QATIRTQFDT CTVLTIAHRL NTIMDYTRVL 1500
VLDKGVVAEF DSPANLIAAR GIFYGMARDA GLA 1533 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0042626; F:ATPase activity, coupled to transmembrane movement of substances; IEA:InterPro.
 GO:0006200; P:ATP catabolic process; IEA:GOC. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR003439; ABC_transporter-like.
 IPR017871; ABC_transporter_CS.
 IPR017940; ABC_transporter_type1.
 IPR001140; ABC_transptr_TM_dom.
 IPR011527; ABC_transptrTM_dom_typ1.
 IPR005292; Multidrug-R_assoc.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00664; ABC_membrane
 PF00005; ABC_tran 
SMART
 SM00382; AAA 
PROSITE
 PS50929; ABC_TM1F
 PS00211; ABC_TRANSPORTER_1
 PS50893; ABC_TRANSPORTER_2 
PRINTS