CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043681
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Citron Rho-interacting kinase 
Protein Synonyms/Alias
  
Gene Name
 CIT 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
1184GGRVSREKAEADAKLubiquitination[1]
1334RYNENLSKYCIRKEIacetylation[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1640 AA 
Protein Sequence
XPFVPTLKSD DDTSNFDEPE KNSWVSSSPC QLSPSGFSGE ELPFVGFSYS KALGILGRSE 60
SVVSGLDSPA KTSSMEKKLL IKSKELQDSQ DKCHKMEQEM TRLHRRVSEV EAVLSQKEVE 120
LKASETQRSL LEQDLATYIT ECSSLKRSLE QARMEVSQED DKALQLLHDI REQSRKLQEI 180
KEQEYQAQVE EMRLMMNQLE EDLVSARRRS DLYESELRES RLAAEEFKRK ATECQHKLLK 240
AKDQGKPEVG EYAKLEKINA EQQLKIQELQ EKLEKAVKAS TEATELLQNI RQAKERAERE 300
LEKLQNREDS SEGIRKKLVE AEELEEKHRE AQVSAQHLEV HLKQKEQHYE EKIKVLDNQI 360
KKDLADKETL ENMMQRHEEE AHEKGKILSE QKAMINAMDS KIRSLEQRIV ELSEANKLAA 420
NSSLFTQRNM KAQEEMISEL RQQKFYLETQ AGKLEAQNRK LEEQLEKISH QDHSDKNRLL 480
ELETRLREVS LEHEEQKLEL KRQLTELQLS LQERESQLTA LQAARAALES QLRQAKTELE 540
ETTAEAEEEI QALTAHRDEI QRKFDALRNS CTVITDLEEQ LNQLTEDNAE LNNQNFYLSK 600
QLDEASGAND EIVQLRSEVD HLRREITERE MQLTSQKQTM EALKTTCTML EEQVMDLEAL 660
NDELLEKERQ WEAWRSVLGD EKSQFECRVR ELQRMLDTEK QSRARADQRI TESRQVVELA 720
VKEHKAEILA LQQALKEQKL KAESLSDKLN DLEKKHAMLE MNARSLQQKL ETERELKQRL 780
LEEQAKLQQQ MDLQKNHIFR LTQGLQEALD RADLLKTERS DLEYQLENIQ VLYSHEKVKM 840
EGTISQQTKL IDFLQAKMDQ PAKKKKVPLQ YNELKLALEK EKARCAELEE ALQKTRIELR 900
SAREEAAHRK ATDHPHPSTP ATARQQIAMS AIVRSPEHQP SAMSLLAPPS SRRKESSTPE 960
EFSRRLKERM HHNIPHRFNV GLNMRATKCA VCLDTVHFGR QASKCLECQV MCHPKCSTCL 1020
PATCGLPAEY ATHFTEAFCR DKMNSPGLQT KEPSSSLHLE GWMKVPRNNK RGQQGWDRKY 1080
IVLEGSKVLI YDNEAREAGQ RPVEEFELCL PDGDVSIHGA VGASELANTA KADVPYILKM 1140
ESHPHTTCWP GRTLYLLAPS FPDKQRWVTA LESVVAGGRV SREKAEADAK LLGNSLLKLE 1200
GDDRLDMNCT LPFSDQVVLV GTEEGLYALN VLKNSLTHVP GIGAVFQIYI IKDLEKLLMI 1260
AGEERALCLV DVKKVKQSLA QSHLPAQPDI SPNIFEAVKG CHLFGAGKIE NGLCICAAMP 1320
SKVVILRYNE NLSKYCIRKE IETSEPCSCI HFTNYSILIG TNKFYEIDMK QYTLEEFLDK 1380
NDHSLAPAVF AASSNSFPVS IVQVNSAGQR EEYLLCFHEF GVFVDSYGRR SRTDDLKWSR 1440
LPLAFAYREP YLFVTHFNSL EVIEIQARSS AGTPARAYLD IPNPRYLGPA ISSGAIYLAS 1500
SYQDKLRVIC CKGNLVKESG TEHHRGPSTS RSSPNKRGPP TYNEHITKRV ASSPAPPEGP 1560
SHPREPSTPH RYREGRTELR RDKSPGRPLE REKSPGRMLS TRRERSPGRL FEDSSRGRLP 1620
AGAVRTPLSQ VNKVWDQSSV 1640 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
 GO:0005083; F:small GTPase regulator activity; IEA:InterPro.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro. 
Interpro
 IPR000961; AGC-kinase_C.
 IPR001180; Citron.
 IPR017405; Citron_Rho-interacting_kinase.
 IPR011993; PH_like_dom.
 IPR017892; Pkinase_C.
 IPR001849; Pleckstrin_homology.
 IPR002219; Prot_Kinase_C-like_PE/DAG-bd. 
Pfam
 PF00780; CNH
 PF00433; Pkinase_C 
SMART
 SM00109; C1
 SM00036; CNH
 SM00233; PH
 SM00133; S_TK_X 
PROSITE
 PS51285; AGC_KINASE_CTER
 PS50219; CNH
 PS50003; PH_DOMAIN
 PS00479; ZF_DAG_PE_1
 PS50081; ZF_DAG_PE_2 
PRINTS