CPLM-002686

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-002686

UniProt Accession

RU17_HUMAN; P08621; B3KUA3; P78493; P78494; Q15364; Q15686; Q15687; Q15689; Q99377; Q9UE45; Q9UE46; Q9UE47; Q9UE48; Q9UFQ6

Genbank Protein ID

X04654; X06814; X06815; X06817; X07402; X06816; X06812; X06811; X07401; X07403; M22636; M57939; M57929; M57930; M57932; M57934; M57937; M57939; M57929; M57930; M57932; M57934; M57937; M57935; M57929; M57930; M57932; M57934; AK096783; X84841; AL117507; CH471177; BC001315

Genbank Nucleotide ID

CAA28352.1; CAA29963.1; CAA29964.1; CAA29966.1; CAA30304.1; CAA29965.1; CAA29961.1; CAA29960.1; CAA30303.1; CAA30305.1; AAA03001.1; AAA36572.1; AAA36572.1; AAA36572.1; AAA36572.1; AAA36572.1; AAA36572.1; AAA36573.1; AAA36573.1; AAA36573.1; AAA36573.1; AAA36573.1; AAA36573.1; AAA36571.1; AAA36571.1; AAA36571.1; AAA36571.1; AAA36571.1; BAG53365.1; CAA59278.1; CAB55969.1; EAW52449.1; AAH01315.1

Protein Name

U1 small nuclear ribonucleoprotein 70 kDa

Protein Synonyms/Alias

U1 snRNP 70 kDa; U1-70K; snRNP70

Gene Name

SNRNP70

Gene Synonyms/Alias

RNPU1Z; RPU1; SNRP70; U1AP1

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
103	NAQGDAFKTLFVARV	ubiquitination	[1]
337	GPDGPEEKGRDRDRE	ubiquitination	[1]

Reference

[1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]

Functional Description

Mediates the splicing of pre-mRNA by binding to the loop I region of U1-snRNA. The truncated isoforms cannot bind U1-snRNA.

Sequence Annotation

DOMAIN 103 181 RRM.
MOD_RES 2 2 N-acetylthreonine.
MOD_RES 118 118 N6-acetyllysine.
MOD_RES 226 226 Phosphoserine.
MOD_RES 268 268 Phosphoserine.
MOD_RES 320 320 Phosphoserine.
MOD_RES 410 410 Phosphoserine.

Keyword

3D-structure; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; mRNA processing; Nucleus; Phosphoprotein; Reference proteome; Ribonucleoprotein; RNA-binding.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

437 AA

Protein Sequence

MTQFLPPNLL ALFAPRDPIP YLPPLEKLPH EKHHNQPYCG IAPYIREFED PRDAPPPTRA 60
ETREERMERK RREKIERRQQ EVETELKMWD PHNDPNAQGD AFKTLFVARV NYDTTESKLR 120
REFEVYGPIK RIHMVYSKRS GKPRGYAFIE YEHERDMHSA YKHADGKKID GRRVLVDVER 180
GRTVKGWRPR RLGGGLGGTR RGGADVNIRH SGRDDTSRYD ERDRDRDRER ERRERSRERD 240
KERERRRSRS RDRRRRSRSR DKEERRRSRE RSKDKDRDRK RRSSRSRERA RRERERKEEL 300
RGGGGDMAEP SEAGDAPPDD GPPGELGPDG PDGPEEKGRD RDRERRRSHR SERERRRDRD 360
RDRDRDREHK RGERGSERGR DEARGGGGGQ DNGLEGLGND SRDMYMESEG GDGYLAPENG 420
YLMEAAPE 428

Gene Ontology

GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005681; C:spliceosomal complex; IDA:UniProtKB.
GO:0000166; F:nucleotide binding; IEA:InterPro.
GO:0003723; F:RNA binding; IMP:UniProtKB.
GO:0000398; P:mRNA splicing, via spliceosome; IDA:UniProtKB.
GO:0043484; P:regulation of RNA splicing; IMP:UniProtKB.

Interpro

IPR012677; Nucleotide-bd_a/b_plait.
IPR000504; RRM_dom.
IPR022023; U1snRNP70_N.

Pfam

PF00076; RRM_1
PF12220; U1snRNP70_N

SMART

SM00360; RRM

PROSITE

PS50102; RRM

PRINTS