UniProt Accession

 ATPD_HUMAN; P30049; D6W5Y3; Q6FG90 

Genbank Protein ID

 S87916; S87918; X63422; X63423; CR542218; AC004221; CH471139; CH471139; CH471139; BC002389; BC004426; BC018079 

Genbank Nucleotide ID

 AAA08055.1; ABB76284.1; CAA45016.1; CAA45017.1; CAG47014.1; AAC04304.1; EAW69532.1; EAW69533.1; EAW69534.1; AAH02389.1; AAH04426.1; AAH18079.1 

Protein Name

 ATP synthase subunit delta, mitochondrial 

Protein Synonyms/Alias

 F-ATPase delta subunit 

Gene Name

 ATP5D 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
136	AAKANLEKAQAELVG	acetylation	[1, 2]
136	AAKANLEKAQAELVG	ubiquitination	[3]
165	EANEALVKALE****	acetylation	[4]
165	EANEALVKALE****	ubiquitination	[3]

Reference

 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773] 

Functional Description

 Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. 

Sequence Annotation

 CROSSLNK 136 136 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 ATP synthesis; CF(1); Complete proteome; Direct protein sequencing; Hydrogen ion transport; Ion transport; Isopeptide bond; Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Transit peptide; Transport; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 168 AA 

Protein Sequence

Gene Ontology

 GO:0005759; C:mitochondrial matrix; TAS:Reactome.
 GO:0000275; C:mitochondrial proton-transporting ATP synthase complex, catalytic core F(1); NAS:UniProtKB.
 GO:0046933; F:proton-transporting ATP synthase activity, rotational mechanism; IEA:InterPro.
 GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
 GO:0022857; F:transmembrane transporter activity; IC:UniProtKB.
 GO:0006200; P:ATP catabolic process; NAS:UniProtKB.
 GO:0042776; P:mitochondrial ATP synthesis coupled proton transport; NAS:UniProtKB.
 GO:0006119; P:oxidative phosphorylation; NAS:UniProtKB.
 GO:0022904; P:respiratory electron transport chain; TAS:Reactome.
 GO:0046688; P:response to copper ion; NAS:UniProtKB. 

Interpro

 IPR001469; ATPase_F1-cplx_dsu/esu.
 IPR020547; ATPase_F1-cplx_dsu/esu_C.
 IPR020546; ATPase_F1-cplx_dsu/esu_N. 

Pfam

 PF02823; ATP-synt_DE_N 

SMART

  

PROSITE

  

PRINTS