UniProt Accession

 NXT1_HUMAN; Q9UKK6 

Genbank Protein ID

 AF156957; AL096677; BC000759; BC002687; BC003029; BC003410 

Genbank Nucleotide ID

 AAD54942.1; CAC03437.2; AAH00759.1; AAH02687.1; AAH03029.1; AAH03410.1 

Protein Name

 NTF2-related export protein 1 

Protein Synonyms/Alias

 Protein p15 

Gene Name

 NXT1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
7	*MASVDFKTYVDQAC	ubiquitination	[1, 2]
30	VYYTTMDKRRRLLSR	ubiquitination	[1, 2, 3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Stimulator of protein export for NES-containing proteins. Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5. 

Sequence Annotation

 DOMAIN 16 135 NTF2.  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Nucleus; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 140 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; TAS:ProtInc.
 GO:0005643; C:nuclear pore; TAS:ProtInc.
 GO:0006611; P:protein export from nucleus; IEA:Compara.
 GO:0006405; P:RNA export from nucleus; IEA:Compara. 

Interpro

 IPR002075; NTF2.
 IPR018222; Nuclear_transport_factor_2_euk. 

Pfam

 PF02136; NTF2 

SMART

  

PROSITE

 PS50177; NTF2_DOMAIN 

PRINTS