CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013027
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 YEATS domain-containing protein 2 
Protein Synonyms/Alias
  
Gene Name
 Yeats2 
Gene Synonyms/Alias
 Kiaa1197 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
41ARDAAVQKIETIIKEacetylation[1]
100LKVSEGLKTFDPMAFacetylation[1]
189SSISGSHKRELRNADacetylation[2]
409SLERTPTKVTTAQKVacetylation[1]
415TKVTTAQKVTFSSHGacetylation[1]
449PNPESPGKSFQPITMacetylation[1, 2]
459QPITMSCKIVSGSPIacetylation[1]
769NSKNPSGKGKLLLIPacetylation[1]
771KNPSGKGKLLLIPQGacetylation[1]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
 Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity). 
Sequence Annotation
 DOMAIN 208 318 YEATS.
 MOD_RES 118 118 Phosphoserine (By similarity).
 MOD_RES 446 446 Phosphoserine (By similarity).
 MOD_RES 462 462 Phosphoserine (By similarity).
 MOD_RES 464 464 Phosphoserine (By similarity).
 MOD_RES 470 470 Phosphoserine (By similarity).
 MOD_RES 472 472 Phosphoserine (By similarity).
 MOD_RES 534 534 Phosphoserine (By similarity).
 MOD_RES 573 573 Phosphoserine (By similarity).
 MOD_RES 625 625 Phosphoserine (By similarity).  
Keyword
 Alternative splicing; Coiled coil; Complete proteome; Nucleus; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1407 AA 
Protein Sequence
MSGIKRTIKE TDPDYEDVSV ALPNKRHKAI ESSARDAAVQ KIETIIKEQF ALEMKNKEHE 60
IDVIDQRLIE ARRMMDKLRA CIVANYYASA GLLKVSEGLK TFDPMAFNHP AIKKFLESPS 120
RSSSPTNQRS ETPSANHSES DSLSQHNDFL SDKDNNSNVD VEERPPSTGE QRPSRKAGRD 180
TSSISGSHKR ELRNADLTGD ETSRLFVKKT IVVGNVSKYI PPDKREENDQ STHKWMVYVR 240
GSRREPSINH FVKKVWFFLH PSYKPNDLVE VREPPFHLTR RGWGEFPVRV QVHFKDSQNK 300
RIDIIHNLKL DRTYTGLQTL GAETVVDVEL HRHSLGEDSV YPQSSESDVC DAPPPTLTLP 360
AAVKASAVAQ SPEPAAAAPV GEGFPETTEA ERHSTFYSLP SSLERTPTKV TTAQKVTFSS 420
HGNSAFQPIA SSCKIVPQSQ VPNPESPGKS FQPITMSCKI VSGSPISTPS PSPLPRTPTS 480
TPVHLKQGTA SSGVSNPHVI VDKPGQVIGA STPSTGSPTS KLPVASQASQ GTGSPIPKIH 540
GSSFLTSTVK QEESLFASMP PLCPIGSHPK VQSPKAVTGG LGAFTKVIIK QEPGEAPHVS 600
TTGAASQSAF PQYVTVKGGH MIAVSPQKQV ISAGEGTTQS PKIAPSKVVG VPVGSALPST 660
VKQAVAISSG QILVAKASSS VTKAVGPKQV VTQGVAKAIV SGGGGTIVAQ PVQTLTKTQV 720
TAAGPQKSGS QGSVMATLQL PATNLANLAN LPPGTKLYLT TNSKNPSGKG KLLLIPQGAI 780
LRATNNANLQ SGSAAAGGSG SSGAGGGSGG GGGSGAGGTP STSGPGGGPQ HLTYTSYILK 840
QTPQGTFLVG QPSPQTPGKQ LTTASVVQGT LGVSSSSAQG QQTLKVISGQ KTTLFTQAAT 900
AGQASLLKLP DNTLKSVPAA PQLAKPGTTM LRVAGGVITA APSPAVAFSA NGAVHQSEGS 960
TPVSSSVGSI IKTPGQPQVC VSQATMATCK GPAAVAGTAA SLVSAPSSIS GKATVSGLLK 1020
VHSAQSSPQQ AVLTIPSQLK PLSINTSGGV QTVLMPVNKV VQSFSTSKLP TTVLPISVPN 1080
QAAPSSAPVA IAKVKTEPET PGPNCISQEN QVAVKTEESS ELSNYVIKVD HLETIQQLLT 1140
AVVKKIPLIT AKGDDASCFS AKSLEQYYGW NIGKRRAAEW QRAMTVRKVL QEILEKNPRF 1200
HHLTPLKTKH IAHWCRCHGY TPPDPESLRH DGDSIEDVLT QIDSEPECLS SFSTADDLCR 1260
KLEDLQQFQK REPENEEEVD ILSLSEPLKT NIKKEQEEKQ EEMRFYLPPT PGSGFVGDIT 1320
QKIGITLQPV ALHRNMYASV VEDMILKATE QLVSDILRQA LAVGYQTASP NRIPKEITVS 1380
NIHQAICNIP FLDFLTNKHM GRLNEDQ 1407 
Gene Ontology
 GO:0005671; C:Ada2/Gcn5/Ada3 transcription activator complex; IDA:MGI.
 GO:0072686; C:mitotic spindle; IDA:MGI.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0043966; P:histone H3 acetylation; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara. 
Interpro
 IPR005033; YEATS. 
Pfam
 PF03366; YEATS 
SMART
  
PROSITE
 PS51037; YEATS 
PRINTS