UniProt Accession

 MOT4_HUMAN; O15427; B3KXG8; Q2M1P8 

Genbank Protein ID

 U81800; AK127319; BC112267; BC112269 

Genbank Nucleotide ID

 AAC52015.1; BAG54480.1; AAI12268.1; AAI12270.1 

Protein Name

 Monocarboxylate transporter 4 

Protein Synonyms/Alias

 MCT 4; Solute carrier family 16 member 3 

Gene Name

 SLC16A3 

Gene Synonyms/Alias

 MCT4 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
415	FCIRKKPKEPQPEVA	ubiquitination	[1]
428	VAAAEEEKLHKPPAD	ubiquitination	[1, 2]
431	AEEEKLHKPPADSGV	ubiquitination	[1, 2, 3, 4]
448	REVEHFLKAEPEKNG	ubiquitination	[1, 2, 3, 4]
453	FLKAEPEKNGEVVHT	ubiquitination	[1, 2, 3, 4]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity). 

Sequence Annotation

 MOD_RES 460 460 Phosphothreonine.
 MOD_RES 464 464 Phosphoserine.  

Keyword

 Cell membrane; Complete proteome; Direct protein sequencing; Membrane; Phosphoprotein; Reference proteome; Symport; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 465 AA 

Protein Sequence

Gene Ontology

 GO:0015629; C:actin cytoskeleton; IDA:HPA.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0031965; C:nuclear membrane; IDA:HPA.
 GO:0008028; F:monocarboxylic acid transmembrane transporter activity; TAS:ProtInc.
 GO:0015355; F:secondary active monocarboxylate transmembrane transporter activity; IEA:InterPro.
 GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
 GO:0007596; P:blood coagulation; TAS:Reactome.
 GO:0050900; P:leukocyte migration; TAS:Reactome.
 GO:0006090; P:pyruvate metabolic process; TAS:Reactome. 

Interpro

 IPR011701; MFS.
 IPR020846; MFS_dom.
 IPR016196; MFS_dom_general_subst_transpt.
 IPR004743; Monocarb_transpt. 

Pfam

 PF07690; MFS_1 

SMART

  

PROSITE

 PS50850; MFS 

PRINTS