UniProt Accession

 MAP6_RAT; Q63560; O88748; Q6AYX8 

Genbank Protein ID

 X93495; AJ002556; BC078848 

Genbank Nucleotide ID

 CAA63762.1; CAA05555.1; AAH78848.1 

Protein Name

 Microtubule-associated protein 6 

Protein Synonyms/Alias

 MAP-6; 145-kDa STOP; STOP145; Stable tubule-only polypeptide; STOP 

Gene Name

 Map6 

Gene Synonyms/Alias

 Mtap6 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
21	RFWNQLDKADIAVPL	acetylation	[1]
174	GDHPWIPKPVQIPAT	acetylation	[1]
226	AGVPAAGKASGADQR	ubiquitination	[2]
238	DQRDTRRKAGPAWMV	ubiquitination	[2]
254	RTEGHEEKPLPPAQS	acetylation	[1]
254	RTEGHEEKPLPPAQS	ubiquitination	[2]
490	WTDIKPVKPIKAKPQ	ubiquitination	[2]
521	QFKGEASKPTTADNK	ubiquitination	[2]
528	KPTTADNKVVDRRRI	ubiquitination	[2]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Involved in microtubule stabilization in many cell types, including neuronal cells. Specifically has microtubule cold stabilizing activity. 

Sequence Annotation

 REPEAT 222 267 Mc-1.
 REPEAT 268 313 Mc-2.
 REPEAT 314 359 Mc-3.
 REPEAT 360 405 Mc-4.
 REPEAT 406 451 Mc-5.
 REGION 1 15 Calmodulin-binding.
 REGION 116 139 Mn 1.
 REGION 124 138 Calmodulin-binding.
 REGION 151 174 Mn 2.
 REGION 160 174 Calmodulin-binding.
 REGION 187 201 Calmodulin-binding.
 REGION 222 451 5 X approximate tandem repeat Mc.
 REGION 235 249 Calmodulin-binding.
 REGION 280 294 Calmodulin-binding.
 REGION 325 339 Calmodulin-binding.
 REGION 373 387 Calmodulin-binding.
 REGION 421 435 Calmodulin-binding.
 REGION 473 496 Mn 3.
 REGION 481 495 Calmodulin-binding.
 REGION 532 546 Calmodulin-binding.
 REGION 559 573 Calmodulin-binding.
 MOD_RES 108 108 Phosphoserine (By similarity).
 MOD_RES 141 141 Phosphotyrosine (By similarity).
 MOD_RES 681 681 Phosphoserine (By similarity).
 MOD_RES 736 736 Phosphoserine (By similarity).
 MOD_RES 951 951 Phosphoserine (By similarity).
 LIPID 5 5 S-palmitoyl cysteine (By similarity).
 LIPID 10 10 S-palmitoyl cysteine (By similarity).
 LIPID 11 11 S-palmitoyl cysteine (By similarity).  

Keyword

 Alternative splicing; Calmodulin-binding; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Golgi apparatus; Lipoprotein; Microtubule; Palmitate; Phosphoprotein; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 952 AA 

Protein Sequence

Gene Ontology

 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0007026; P:negative regulation of microtubule depolymerization; IEA:InterPro. 

Interpro

 IPR024963; STOP/FAM154.
 IPR007882; STOP/MAP6. 

Pfam

 PF05217; STOP 

SMART

  

PROSITE

  

PRINTS