CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010092
UniProt Accession
Genbank Protein ID
 U00089 
Genbank Nucleotide ID
Protein Name
 Signal recognition particle receptor FtsY 
Protein Synonyms/Alias
 SRP receptor 
Gene Name
 ftsY 
Gene Synonyms/Alias
 MPN_425; MP416 
Created Date
 July 27, 2013 
Organism
 Mycoplasma pneumoniae (strain ATCC 29342 / M129) 
NCBI Taxa ID
 272634 
Lysine Modification
Position
Peptide
Type
References
6**MSFIHKLIQKFKPacetylation[1]
Reference
 [1] Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium.
 van Noort V, Seebacher J, Bader S, Mohammed S, Vonkova I, Betts MJ, Kühner S, Kumar R, Maier T, O'Flaherty M, Rybin V, Schmeisky A, Yus E, Stülke J, Serrano L, Russell RB, Heck AJ, Bork P, Gavin AC.
 Mol Syst Biol. 2012 Feb 28;8:571. [PMID: 22373819] 
Functional Description
 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) (By similarity). 
Sequence Annotation
 NP_BIND 143 150 GTP (By similarity).
 NP_BIND 225 229 GTP (By similarity).
 NP_BIND 289 292 GTP (By similarity).  
Keyword
 Cell membrane; Complete proteome; Cytoplasm; GTP-binding; Membrane; Nucleotide-binding; Receptor; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 348 AA 
Protein Sequence
MSFIHKLIQK FKPKKKLVDQ VQQAVQEKSF FQANQKSYYQ GLNKSANSFA NTINKLAANY 60
VTVNEQFQES LFEELVLLDI GYHAATKICD AIVQELKLQR VSDPQLIQEI IVDKLIVYYI 120
QDKLFETDLT VEANKTNVYL FVGVNGVGKT TSLAKLADQL TKQNKRVLMV AGDTFRAGAV 180
AQLAEWAQRI GCDIVLPNPK EETPAVIFRG VQQGIQNEYD FVLCDTSGRL QNKTNLMNEL 240
KKIYQIVQKV SSAKPQETLL VLDGTTGQSG LAQAKVFNEF TELTGIILTK MDSSSKGGII 300
LAIKDLFNLP VKLIGFGETT ADLAAFDLEQ YVLGLTKNLS LNHEPNQT 348 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0031226; C:intrinsic to plasma membrane; IEA:HAMAP.
 GO:0005525; F:GTP binding; IEA:HAMAP.
 GO:0003924; F:GTPase activity; IEA:HAMAP.
 GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; IEA:InterPro. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR027417; P-loop_NTPase.
 IPR013822; Signal_recog_particl_SRP54_hlx.
 IPR004390; SR_rcpt_FtsY.
 IPR000897; SRP54_GTPase_dom. 
Pfam
 PF00448; SRP54
 PF02881; SRP54_N 
SMART
 SM00382; AAA
 SM00962; SRP54
 SM00963; SRP54_N 
PROSITE
 PS00300; SRP54 
PRINTS