CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030268
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 A kinase (PRKA) anchor protein (Gravin) 12 
Protein Synonyms/Alias
 A kinase (PRKA) anchor protein (Gravin) 12, isoform CRA_b 
Gene Name
 Akap12 
Gene Synonyms/Alias
 mCG_140773 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
159VGFKKVFKFVGFKFTubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1684 AA 
Protein Sequence
MGAGSSTEQR SPEQPAESDT PSELELSGHG PAAEASGAAG DPADADPATK LPQKNGQLSA 60
VNGVAEQEDV HVQEESQDGQ EEEVTVEDVG QRESEDVKEK DRAKEMAASS TVVEDITKDE 120
QEETPEIIEQ IPASESNVEE MAQAAESQAN DVGFKKVFKF VGFKFTVKKD KNEKSDTVQL 180
LTVKKDEGEG AEASVGAGDH QEPGVETVGE SASKESELKQ STEKQEGTLK QAQSSTEIPL 240
QAESGQGTEE EAAKDGEENR EKEPTKPLES PTSPVSNETT SSFKKFFTHG WAGWRKKTSF 300
KKPKEDDLET SEKRKEQEAE KVDEEEGEKT EPAPAEEQEP AEGTDQARLS ADYEKVELPL 360
EDQVGDLEAL SEKCAPLATE VFDEKTEAHQ EVVAEVHVST VEKMTKGQGG AEVEGDVVVE 420
GSGESLPPEK LAETQEVPQE AEPVEELMKT KEVCVSGGDH TQLTDLSPEE KMLPKHPEGI 480
VSEVEMLSSQ ERIKVQGSPL KKLFSSSGLK KLSGKKQKGK RGGGGGDEEP GEYQHIQTES 540
PESADEQKGE SSASSPEEPE EIACLEKGPS EAPQEAEAEE GATSDGEKKR EGITPWASFK 600
KMVTPKKRVR RPSESDKEEE LDKVKSATLS STESTASGMQ DEVRAVGEEQ RSEEPKRRVD 660
TSVSWEALIC VGSSKKRARK ASSSDDEGGP RTLGGDGHRA EEASKDKEAD ALPASTQEQD 720
QAHGSSSPEP AGSPSEGEGV STWESFKRLV TPRKKSKSKL EERAEDSGAE QLASEIEPSR 780
EESWVSIKKF IPGRRKKRAD GKQEQAAVED SGPGEINEDD PDVPAVVPLS EYDAVEREKL 840
EAQRAQENVE LPQLKGAVYV SEELSKTLVH TVSVAVIDGT RAVTSAEERS PSWISASMTE 900
PLEHAEGVAT PPVGEVTEKD ITAEATPALA QTLPGGKDAH DDIVTSEVDF TSEAVTAAET 960
TEALRAEELT EASGAEETTD MVSAVSQLSD SPDTTEEATP VQEVEGGMLD TEEQERQTQA 1020
VLQAVADKVK EDSQVPATQT LQRAGPKALE KVEEVEEDSE VLATEKEKDV VPEGPVQEAE 1080
TEHLAQGSET VQATPESLEV PEVTEDVDRA TTCQVIKHQQ LMEQAVAPES SETLTDSETN 1140
GSTPLADSDT PNGTQQDETV DSQDSNAIAA VKQSQVTEEE AAAAQTEGPS TPSSFPAQEE 1200
HREKPGRDVL EPTQALAAGA VPILAKAEVG QEGEAGQFDG EKVKDGQCVK ELEVPVHTGP 1260
NSQKTADLTR DSEVMEVARC QETESNEEQS ISPEKREMGT DVEKEETETK TEQASEEHEQ 1320
ETAAPEHEGT HPKPVLTADM PHSERGKALG SLEGSPSLPD QDKADCIEVQ VQSSDTPVTQ 1380
TTEAVKKVEE TVATSEMDES LECAGAQSLP AEKLSETGGY GTLQHGEDTV PQGPESQAES 1440
IPIIVTPAPE SILHSDLQRE VSASQKQRSD EDNKPDAGPD AAGKESAARE KILRAEPEIL 1500
ELESKSNKIV QSVIQTAVDQ FARTETAPET HASDLQNQVP VMQADSQGAQ QMLDKDESDL 1560
QVSPQDGTLS AVAQEGLAVS DSSEGMSKAS EMITTLAVES ASVKESVEKL PLQCKDEKEH 1620
AADGPQHQSL AKAEADASGN LTKESPDTNG PKLTEEGDAL KEEMNKAQTE EDDLQEPKGD 1680
LTES 1684 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
 GO:0030159; F:receptor signaling complex scaffold activity; TAS:MGI.
 GO:0030819; P:positive regulation of cAMP biosynthetic process; IEA:Compara.
 GO:0010739; P:positive regulation of protein kinase A signaling cascade; IEA:Compara.
 GO:0006605; P:protein targeting; IEA:InterPro.
 GO:0007165; P:signal transduction; TAS:MGI. 
Interpro
 IPR001573; Pkinase-A_anch_WSK-motif.
 IPR018459; RII_binding_1. 
Pfam
 PF10522; RII_binding_1
 PF03832; WSK 
SMART
  
PROSITE
  
PRINTS