UniProt Accession

 LYAR_HUMAN; Q9NX58; D3DVS4; Q6FI78; Q9NYS1 

Genbank Protein ID

 AL136750; AK000432; CR533548; CH471131; CH471131; CH471131; BC015796; AF229835 

Genbank Nucleotide ID

 CAB66684.1; BAA91162.1; CAG38579.1; EAW82437.1; EAW82438.1; EAW82439.1; AAH15796.1; AAF42870.1 

Protein Name

 Cell growth-regulating nucleolar protein 

Protein Synonyms/Alias

  

Gene Name

 LYAR 

Gene Synonyms/Alias

 PNAS-5 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
80	KQQAWIQKISELIKR	ubiquitination	[1]
374	TFKLLKDKVKLVK**	ubiquitination	[2]

Reference

 [1] A data set of human endogenous protein ubiquitination sites.
 Shi Y, Chan DW, Jung SY, Malovannaya A, Wang Y, Qin J.
 Mol Cell Proteomics. 2011 May;10(5):M110.002089. [PMID: 20972266]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

 ZN_FING 6 25 C2HC-type 1.
 ZN_FING 33 51 C2HC-type 2.
 METAL 6 6 Zinc 1 (By similarity).
 METAL 9 9 Zinc 1 (By similarity).
 METAL 21 21 Zinc 1 (By similarity).
 METAL 25 25 Zinc 1 (By similarity).
 METAL 33 33 Zinc 2 (By similarity).
 METAL 36 36 Zinc 2 (By similarity).
 METAL 48 48 Zinc 2 (By similarity).
 METAL 51 51 Zinc 2 (By similarity).
 MOD_RES 215 215 Phosphoserine.
 MOD_RES 244 244 Phosphoserine.  

Keyword

 Coiled coil; Complete proteome; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 379 AA 

Protein Sequence

Gene Ontology

 GO:0005730; C:nucleolus; IDA:LIFEdb.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. 

Interpro

 IPR014898; Znf_C2H2_LYAR. 

Pfam

 PF08790; zf-LYAR 

SMART

  

PROSITE

  

PRINTS