UniProt Accession

 HMGN5_HUMAN; P82970; Q5JSL1 

Genbank Protein ID

 AF250329; AF250330; AK094058; AL391294; CH471104; BC005342 

Genbank Nucleotide ID

 AAK14062.1; AAK14063.1; CAI39708.1; EAW98582.1; AAH05342.1 

Protein Name

 High mobility group nucleosome-binding domain-containing protein 5 

Protein Synonyms/Alias

 Nucleosome-binding protein 1 

Gene Name

 HMGN5 

Gene Synonyms/Alias

 NSBP1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
35	VPVTPEVKPKRTSSS	acetylation	[1]
48	SSRKMKTKSDMMEEN	ubiquitination	[2]
95	TEAPASEKEIVEVKE	acetylation	[1, 3]
101	EKEIVEVKEENIEDA	sumoylation	[4]

Reference

 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Site-specific identification of SUMO-2 targets in cells reveals an inverted SUMOylation motif and a hydrophobic cluster SUMOylation motif.
 Matic I, Schimmel J, Hendriks IA, van Santen MA, van de Rijke F, van Dam H, Gnad F, Mann M, Vertegaal AC.
 Mol Cell. 2010 Aug 27;39(4):641-52. [PMID: 20797634] 

Functional Description

 Preferentially binds to euchromatin and modulates cellular transcription by counteracting linker histone-mediated chromatin compaction (By similarity). 

Sequence Annotation

 MOD_RES 20 20 Phosphoserine (By similarity).
 MOD_RES 24 24 Phosphoserine (By similarity).
 MOD_RES 31 31 Phosphothreonine.
 MOD_RES 76 76 Phosphotyrosine.  

Keyword

 Chromatin regulator; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 282 AA 

Protein Sequence

Gene Ontology

 GO:0000785; C:chromatin; IEA:InterPro.
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0005654; C:nucleoplasm; IEA:Compara.
 GO:0003682; F:chromatin binding; NAS:UniProtKB.
 GO:0031492; F:nucleosomal DNA binding; IEA:InterPro.
 GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; NAS:UniProtKB.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR000079; HMGN_fam. 

Pfam

 PF01101; HMG14_17 

SMART

 SM00527; HMG17 

PROSITE

 PS00355; HMG14_17 

PRINTS

 PR00925; NONHISHMG17.