Tag | Content |
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CPLM ID | CPLM-000864 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Eukaryotic translation initiation factor 6 |
Protein Synonyms/Alias | eIF-6; B4 integrin interactor; CAB; p27(BBP) |
Gene Name | Eif6 |
Gene Synonyms/Alias | Itgb4bp |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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228 | VFKLNEAKPSTIATS | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May behave as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (GNB2L1)-dependent protein kinase C activity (By similarity). |
Sequence Annotation | MOD_RES 113 113 Phosphotyrosine (By similarity). MOD_RES 165 165 Phosphothreonine. MOD_RES 166 166 Phosphoserine. MOD_RES 174 174 Phosphoserine; by CK1. MOD_RES 175 175 Phosphoserine; by CK1. MOD_RES 235 235 Phosphoserine; by PKC (By similarity). MOD_RES 239 239 Phosphoserine (By similarity). MOD_RES 243 243 Phosphoserine (By similarity). MOD_RES 245 245 Phosphothreonine (By similarity). |
Keyword | Complete proteome; Cytoplasm; Initiation factor; Nucleus; Phosphoprotein; Protein biosynthesis; Reference proteome; Ribosome biogenesis. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 245 AA |
Protein Sequence | MAVRASFENN CEVGCFAKLT NAYCLVAIGG SENFYSVFEG ELSDAIPVVH ASIAGCRIIG 60 RMCVGNRHGL LVPNNTTDQE LQHIRNSLPD SVQIRRVEER LSALGNVTTC NDYVALVHPD 120 LDRETEEILA DVLKVEVFRQ TVADQVLVGS YCVFSNQGGL VHPKTSIEDQ DELSSLLQVP 180 LVAGTVNRGS EVIAAGMVVN DWCAFCGLDT TSTELSVVES VFKLNEAKPS TIATSMRDSL 240 IDSLT 245 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005638; C:lamin filament; IDA:MGI. GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell. GO:0043023; F:ribosomal large subunit binding; IEA:HAMAP. GO:0043022; F:ribosome binding; ISS:UniProtKB. GO:0003743; F:translation initiation factor activity; IEA:HAMAP. GO:0042256; P:mature ribosome assembly; ISS:UniProtKB. GO:0042273; P:ribosomal large subunit biogenesis; IEA:HAMAP. GO:0000054; P:ribosomal subunit export from nucleus; IEA:HAMAP. |
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