UniProt Accession

 YES_HUMAN; P07947; A6NLB3; D3DUH1 

Genbank Protein ID

 M15990; AP001178; CH471113; CH471113; BC048960 

Genbank Nucleotide ID

 AAA35735.1; EAX01709.1; EAX01710.1; AAH48960.1 

Protein Name

 Tyrosine-protein kinase Yes 

Protein Synonyms/Alias

 Proto-oncogene c-Yes; p61-Yes 

Gene Name

 YES1 

Gene Synonyms/Alias

 YES 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
191	VRESETTKGAYSLSI	ubiquitination	[1, 2]
235	AQFDTLQKLVKHYTE	ubiquitination	[1, 2]
437	QGAKFPIKWTAPEAA	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis. 

Sequence Annotation

 DOMAIN 91 152 SH3.
 DOMAIN 158 255 SH2.
 DOMAIN 277 530 Protein kinase.
 NP_BIND 283 291 ATP (By similarity).
 ACT_SITE 396 396 Proton acceptor (By similarity).
 BINDING 305 305 ATP (By similarity).
 MOD_RES 11 11 Phosphoserine.
 MOD_RES 21 21 Phosphothreonine.
 MOD_RES 26 26 Phosphoserine.
 MOD_RES 32 32 Phosphotyrosine.
 MOD_RES 40 40 Phosphoserine.
 MOD_RES 111 111 Phosphoserine.
 MOD_RES 194 194 Phosphotyrosine.
 MOD_RES 195 195 Phosphoserine.
 MOD_RES 222 222 Phosphotyrosine.
 MOD_RES 223 223 Phosphotyrosine.
 MOD_RES 336 336 Phosphotyrosine.
 MOD_RES 345 345 Phosphotyrosine.
 MOD_RES 426 426 Phosphotyrosine; by autocatalysis.
 MOD_RES 446 446 Phosphotyrosine.
 MOD_RES 537 537 Phosphotyrosine; by CSK.
 LIPID 2 2 N-myristoyl glycine (By similarity).
 LIPID 3 3 S-palmitoyl cysteine; in membrane form  

Keyword

 3D-structure; ATP-binding; Cell membrane; Complete proteome; Cytoplasm; Cytoskeleton; Kinase; Lipoprotein; Membrane; Myristate; Nucleotide-binding; Palmitate; Phosphoprotein; Polymorphism; Proto-oncogene; Reference proteome; SH2 domain; SH3 domain; Transferase; Tyrosine-protein kinase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 543 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
 GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; TAS:BHF-UCL.
 GO:0007596; P:blood coagulation; TAS:Reactome.
 GO:0038096; P:Fc-gamma receptor signaling pathway involved in phagocytosis; TAS:Reactome.
 GO:0015758; P:glucose transport; IEA:Compara.
 GO:0045087; P:innate immune response; TAS:Reactome.
 GO:0050900; P:leukocyte migration; TAS:Reactome.
 GO:0046777; P:protein autophosphorylation; IEA:Compara.
 GO:0043114; P:regulation of vascular permeability; TAS:BHF-UCL.
 GO:0031295; P:T cell costimulation; TAS:Reactome. 

Interpro

 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
 IPR000980; SH2.
 IPR001452; SH3_domain.
 IPR008266; Tyr_kinase_AS.
 IPR020635; Tyr_kinase_cat_dom. 

Pfam

 PF07714; Pkinase_Tyr
 PF00017; SH2
 PF00018; SH3_1 

SMART

 SM00252; SH2
 SM00326; SH3
 SM00219; TyrKc 

PROSITE

 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00109; PROTEIN_KINASE_TYR
 PS50001; SH2
 PS50002; SH3 

PRINTS

 PR00401; SH2DOMAIN.
 PR00452; SH3DOMAIN.
 PR00109; TYRKINASE.