CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043013
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Electron transfer flavoprotein subunit alpha, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 ETFA 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
69KVAQDLCKVAGIAKVacetylation[1]
85VAQHDVYKGLLPEELacetylation[1]
85VAQHDVYKGLLPEELubiquitination[2, 3, 4]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 289 AA 
Protein Sequence
MFRAAAPGQL RRAASLLRFQ STLVIAEHAN DSLAPITLNT ITAATRLGGE VSCLVAGTKC 60
DKVAQDLCKV AGIAKVLVAQ HDVYKGLLPE ELTPLILATQ KQFNYTHICA GASAFGKNLL 120
PRVAAKLEVA PISDIIAIKS PDTFVRTIYA GNALCTVKCD EKVKVFSVRG TSFDAAATSG 180
GSASSEKASS TSPVEISEWL DQKLTKSDRP ELTGAKVVVS GDGVSLLLPR LECNGTISAH 240
RHLHLPGSSD SPASASRVAG ITGRGLKSGE NFKLLYDLAD QLHAAVGAS 289 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:HPA. 
Interpro
 IPR014730; ETF_a/b_N.
 IPR014731; ETF_asu_C.
 IPR014729; Rossmann-like_a/b/a_fold. 
Pfam
 PF01012; ETF
 PF00766; ETF_alpha 
SMART
 SM00893; ETF 
PROSITE
  
PRINTS