UniProt Accession

 KAD2_RAT; P29410; Q6P7C6 

Genbank Protein ID

 D13061; BC061727 

Genbank Nucleotide ID

 BAA02378.1; AAH61727.1 

Protein Name

 Adenylate kinase 2, mitochondrial 

Protein Synonyms/Alias

 AK 2; ATP-AMP transphosphorylase 2; ATP:AMP phosphotransferase; Adenylate monophosphate kinase; Adenylate kinase 2, mitochondrial, N-terminally processed 

Gene Name

 Ak2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
62	ASGSELGKKLKATMD	acetylation	[1]
106	DGFPRTVKQAEMLDD	acetylation	[1]
117	MLDDLMDKRKEKLDS	acetylation	[1]
164	NPPKEAMKDDITGEP	acetylation	[1]
181	RRSDDNEKALKTRLE	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis (By similarity). 

Sequence Annotation

 NP_BIND 25 30 ATP (By similarity).
 NP_BIND 72 74 AMP (By similarity).
 NP_BIND 100 103 AMP (By similarity).
 NP_BIND 151 152 ATP (By similarity).
 REGION 45 74 NMPbind (By similarity).
 REGION 141 178 LID (By similarity).
 BINDING 46 46 AMP (By similarity).
 BINDING 51 51 AMP (By similarity).
 BINDING 107 107 AMP (By similarity).
 BINDING 142 142 ATP (By similarity).
 BINDING 175 175 AMP (By similarity).
 BINDING 186 186 AMP (By similarity).
 BINDING 214 214 ATP; via carbonyl oxygen (By similarity).
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 93 93 N6-acetyllysine (By similarity).
 DISULFID 42 92 By similarity.  

Keyword

 Acetylation; Alternative splicing; ATP-binding; Complete proteome; Disulfide bond; Kinase; Mitochondrion; Nucleotide-binding; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 239 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:RGD.
 GO:0005743; C:mitochondrial inner membrane; IEA:Compara.
 GO:0005758; C:mitochondrial intermembrane space; IDA:RGD.
 GO:0097226; C:sperm mitochondrial sheath; IEA:Compara.
 GO:0004017; F:adenylate kinase activity; IDA:RGD.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0046083; P:adenine metabolic process; TAS:RGD.
 GO:0006172; P:ADP biosynthetic process; IDA:RGD.
 GO:0046033; P:AMP metabolic process; IDA:RGD.
 GO:0046034; P:ATP metabolic process; IDA:RGD.
 GO:0007420; P:brain development; IEP:RGD.
 GO:0046060; P:dATP metabolic process; IDA:RGD.
 GO:0001889; P:liver development; IEP:RGD.
 GO:0006119; P:oxidative phosphorylation; IEP:RGD.
 GO:0097066; P:response to thyroid hormone stimulus; IEP:RGD. 

Interpro

 IPR006259; Adenyl_kin_sub.
 IPR000850; Adenylate_kin.
 IPR007862; Adenylate_kinase_lid-dom.
 IPR027417; P-loop_NTPase. 

Pfam

 PF00406; ADK
 PF05191; ADK_lid 

SMART

  

PROSITE

 PS00113; ADENYLATE_KINASE 

PRINTS

 PR00094; ADENYLTKNASE.