CPLM-009537

Genbank Nucleotide ID

Rho-related GTP-binding protein RhoB

Protein Synonyms/Alias

Mus musculus (Mouse)

Position	Peptide	Type	References
118	PIILVANKKDLRSDE	ubiquitination	[1]
135	RTELARMKQEPVRTD	acetylation	[2]
135	RTELARMKQEPVRTD	ubiquitination	[1]
162	DYLECSAKTKEGVRE	ubiquitination	[1]

[1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
[2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]

Functional Description

Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells.

NP_BIND 12 19 GTP (By similarity).
NP_BIND 59 63 GTP (By similarity).
NP_BIND 117 120 GTP (By similarity).
MOTIF 34 42 Effector region (Potential).
MOD_RES 154 154 Phosphotyrosine.
MOD_RES 193 193 Cysteine methyl ester (By similarity).
LIPID 189 189 S-palmitoyl cysteine (By similarity).
LIPID 192 192 S-palmitoyl cysteine (By similarity).
LIPID 193 193 S-farnesyl cysteine; in plasma membrane
LIPID 193 193 S-geranylgeranyl cysteine; in endosomal

Angiogenesis; Apoptosis; Cell adhesion; Cell membrane; Complete proteome; Developmental protein; Differentiation; Direct protein sequencing; Endosome; GTP-binding; Lipoprotein; Membrane; Methylation; Nucleotide-binding; Nucleus; Palmitate; Phosphoprotein; Prenylation; Protein transport; Reference proteome; Transport; Tumor suppressor.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0032154; C:cleavage furrow; ISS:UniProtKB.
GO:0005829; C:cytosol; IEA:Compara.
GO:0010008; C:endosome membrane; ISS:UniProtKB.
GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0005886; C:plasma membrane; ISS:UniProtKB.
GO:0019003; F:GDP binding; IDA:MGI.
GO:0005525; F:GTP binding; TAS:UniProtKB.
GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
GO:0007155; P:cell adhesion; IDA:UniProtKB.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
GO:0070301; P:cellular response to hydrogen peroxide; ISS:UniProtKB.
GO:0071479; P:cellular response to ionizing radiation; ISS:UniProtKB.
GO:0000910; P:cytokinesis; ISS:UniProtKB.
GO:0008333; P:endosome to lysosome transport; ISS:UniProtKB.
GO:0045786; P:negative regulation of cell cycle; IMP:UniProtKB.
GO:0045766; P:positive regulation of angiogenesis; IMP:UniProtKB.
GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB.
GO:0015031; P:protein transport; IEA:UniProtKB-KW.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
GO:0006927; P:transformed cell apoptotic process; IDA:UniProtKB.

IPR027417; P-loop_NTPase.
IPR005225; Small_GTP-bd_dom.
IPR001806; Small_GTPase.
IPR003578; Small_GTPase_Rho.

PR00449; RASTRNSFRMNG.